Tigers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 4:18 a.m.

In MLB action on Tuesday, the Detroit Tigers play the San Diego Padres.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Padres Game Info

• Detroit Tigers (14-9) vs. San Diego Padres (16-7)
• Date: Tuesday, April 22, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: FDSDET and SDPA

Tigers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-116) | SD: (-102)
• Spread: DET: +1.5 (-192) | SD: -1.5 (+158)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Tigers vs Padres Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 1-1, 2.53 ERA vs Nick Pivetta (Padres) - 3-1, 1.57 ERA

The Tigers will give the nod to Jack Flaherty (1-1) versus the Padres and Nick Pivetta (3-1). Flaherty's team is 2-2-0 against the spread in his starts this season. Flaherty's team is 1-1 this season when he starts and they're favored on the moneyline. The Padres are 3-1-0 ATS in Pivetta's four starts that had a set spread. The Padres were the moneyline underdog for one Pivetta start this season -- they lost.

Tigers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (54.3%)

Tigers vs Padres Moneyline

• The moneyline numbers for Tigers vs. Padres reveal Detroit as the favorite (-116) and San Diego as the underdog (-102) on the road.

Tigers vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Tigers. The Padres are +158 to cover, while the Tigers are -192 to cover as a 1.5-run underdog on the runline.

Tigers vs Padres Over/Under

• Tigers versus Padres on April 22 has an over/under of 7.5 runs, with the odds on the over -104 and the under set at -118.

Bet on Detroit Tigers vs. San Diego Padres on FanDuel today!

Tigers vs Padres Betting Trends

• The Tigers have been victorious in eight, or 72.7%, of the 11 contests they have been chosen as favorites in this season.
• Detroit has a record of 8-2 in contests when sportsbooks favor them by -116 or more on the moneyline.
• The Tigers' games have gone over the total in 10 of their 23 opportunities.
• The Tigers are 14-9-0 against the spread in their 23 games with a line set by sportsbooks this season.
• The Padres have a 5-5 record in games they were listed as the moneyline underdog (winning 50% of those games).
• When it has played as a moneyline underdog with odds of -102 or longer, San Diego has a record of 5-5 (50%).
• The Padres have combined with opponents to hit the over on the total 10 times this season for a 10-12-1 record against the over/under.
• The Padres have gone 14-9-0 against the spread this season.

Tigers Player Leaders

• Spencer Torkelson leads Detroit with 24 hits and a team-best slugging percentage of .619. He's batting .286 with an on-base percentage of .392.
• Among the qualifying hitters in baseball, his batting average ranks 44th, his on-base percentage ranks 23rd, and he is eighth in slugging.
• Torkelson will look for his seventh straight game with a hit in this contest. During his last 10 outings he is batting .278 with two doubles, four home runs, six walks and 14 RBI.
• Zach McKinstry leads Detroit with an OBP of .424 this season while batting .314 with 14 walks and 12 runs scored. He's slugging .471.
• He ranks 22nd in batting average, seventh in on-base percentage and 51st in slugging in the major leagues.
• McKinstry takes a four-game streak with at least one hit into this contest. During his last five outings he is hitting .444 with two doubles, a triple, four walks and four RBI.
• Kerry Carpenter has 23 hits this season and has a slash line of .315/.338/.562.
• Carpenter brings a five-game hitting streak into this game. During his last five outings he is batting .474 with a double and an RBI.
• Trey Sweeney is batting .209 with a .274 OBP and eight RBI for Detroit this season.

Padres Player Leaders

• Fernando Tatis Jr. has accumulated a team-best OBP (.424) and slugging percentage (.663), while pacing the Padres in hits (30, while batting .349).
• Including all the qualifying hitters in MLB, he ranks sixth in batting average, seventh in on-base percentage and fourth in slugging percentage.
• Tatis brings a 10-game hitting streak into this game. In his last 10 games he is batting .333 with a triple, six home runs, five walks and 10 RBI.
• Manny Machado is hitting .306 with nine doubles, two home runs and 10 walks. He's slugging .482 with an on-base percentage of .379.
• Including all qualifying hitters, he ranks 26th in batting average, 31st in on-base percentage and 44th in slugging percentage.
• Gavin Sheets has four doubles, three home runs and five walks while batting .344.
• Xander Bogaerts is hitting .269 with eight doubles and 11 walks.

Tigers vs Padres Head to Head

• 4/21/2025: 6-4 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/5/2024: 4-3 DET (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/4/2024: 6-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/2/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 7/23/2023: 3-1 DET (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/22/2023: 14-3 SD (Favorite: Padres, Spread: -1.5, Total: 10, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/21/2023: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/27/2022: 4-3 DET (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/26/2022: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 7/25/2022: 12-4 DET (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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