Tigers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 5:14 a.m.

Monday's slate in the MLB includes a matchup between the Detroit Tigers and the San Diego Padres.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Tigers vs Padres Game Info

• Detroit Tigers (13-9) vs. San Diego Padres (16-6)
• Date: Monday, April 21, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: Fox Sports 1, FDSDET, and SDPA

Tigers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-126) | SD: (+108)
• Spread: DET: -1.5 (+158) | SD: +1.5 (-192)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Tigers vs Padres Probable Starting Pitchers

Probable Pitchers: Keider Montero (Tigers) - 0-1, 9.00 ERA vs Randy Vasquez (Padres) - 1-1, 1.74 ERA

The Tigers will give the nod to Keider Montero (0-1) against the Padres and Randy Vasquez (1-1). Montero and his team failed to cover the spread in his only opportunity this season as a starter. Montero has yet to start a game this season when his team was the moneyline favorite. The Padres have a 3-1-0 ATS record in Vasquez's four starts that had a set spread. The Padres are 2-2 in Vasquez's four starts this season that they were the underdog on the moneyline.

Tigers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (50.5%)

Tigers vs Padres Moneyline

• Looking at the moneyline for Tigers-Padres, Detroit is the favorite at -126, and San Diego is +108 playing on the road.

Tigers vs Padres Spread

• The Padres are at +1.5 on the runline against the Tigers. The Padres are -192 to cover the spread, and the Tigers are +158.

Tigers vs Padres Over/Under

• A total of 8.5 runs has been set for the Tigers-Padres contest on April 21, with the over available at -100 and the under at -122.

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Tigers vs Padres Betting Trends

• The Tigers have been victorious in seven of the 10 contests they have been chosen as favorites in this season.
• This season Detroit has come away with a win seven times in eight chances when named as a favorite of at least -126 on the moneyline.
• The Tigers and their opponents have gone over the total this season in nine of their 22 opportunities.
• The Tigers have posted a record of 13-9-0 against the spread this season.
• The Padres have a 5-4 record in games they were the underdog on the moneyline (winning 55.6% of those games).
• When playing as a moneyline underdog with odds of +108 or longer, San Diego has gone 3-3 (50%).
• The Padres have had an over/under set by bookmakers 22 times, and have combined with opponents to go over the total in nine of those games (9-12-1).
• The Padres have collected a 14-8-0 record ATS this season (covering 63.6% of the time).

Tigers Player Leaders

• Spencer Torkelson leads Detroit in slugging percentage (.638) and total hits (23) this season. He's batting .288 with an on-base percentage of .392.
• Among the qualified batters in the majors, his batting average ranks 42nd, his on-base percentage ranks 24th, and he is seventh in slugging.
• Torkelson hopes to build on a five-game hitting streak in this matchup. During his last five outings he is batting .353 with two doubles, two home runs, five walks and nine RBI.
• Kerry Carpenter has hit five homers this season while driving in 11 runs. He's batting .315 this season and slugging .562 with an on-base percentage of .338.
• Among qualified hitters, he ranks 19th in batting average, 72nd in on-base percentage and 15th in slugging percentage.
• Carpenter has picked up a hit in five games in a row. In his last five games he is batting .474 with a double and an RBI.
• Zach McKinstry leads Detroit in OBP (.400) this season, fueled by 19 hits.
• McKinstry enters this game with three games in a row with at least one hit. In his last five games he is batting .357 with a double, four walks and three RBI.
• Trey Sweeney is batting .222 with a .290 OBP and eight RBI for Detroit this season.

Padres Player Leaders

• Fernando Tatis Jr. has totaled 29 hits with a .436 on-base percentage and a .691 slugging percentage, all club-highs for the Padres. He's batting .358.
• Including all qualifying players in the big leagues, he is third in batting average, fifth in on-base percentage and third in slugging percentage.
• Tatis hopes to build on a nine-game hitting streak in this matchup. During his last 10 outings he is batting .333 with a triple, six home runs, six walks and nine RBI.
• Manny Machado is batting .305 with nine doubles, two home runs and nine walks. He's slugging .488 with an on-base percentage of .374.
• He is currently 24th in batting average, 37th in on-base percentage and 41st in slugging percentage among all qualified hitters.
• Luis Sangel (Reveron) Arraez is batting .287 with three doubles, three home runs and five walks.
• Xander Bogaerts has eight doubles and 10 walks while hitting .267.

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