Giants vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 8:11 a.m.

The San Francisco Giants are among the MLB squads busy on Monday, up against the Milwaukee Brewers.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Giants vs Brewers Game Info

• San Francisco Giants (14-8) vs. Milwaukee Brewers (12-10)
• Date: Monday, April 21, 2025
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and FDSWI

Giants vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-142) | MIL: (+120)
• Spread: SF: -1.5 (+146) | MIL: +1.5 (-178)
• Total: 8 -- Over: (-110) | Under: (-110)

Giants vs Brewers Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Giants) - 3-0, 4.19 ERA vs Quinn Priester (Brewers) - 1-0, 0.90 ERA

The probable starters are Robbie Ray (3-0) for the Giants and Quinn Priester (1-0) for the Brewers. Ray and his team have covered in each of his four starts with a spread this season. Ray's team is 2-0 this season when he starts and they're favored on the moneyline. Priester has started two games with set spreads, and the Brewers went 1-1-0. The Brewers were the moneyline underdog for one Priester start this season -- they won.

Giants vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (55.4%)

Giants vs Brewers Moneyline

• San Francisco is the favorite, -142 on the moneyline, while Milwaukee is a +120 underdog on the road.

Giants vs Brewers Spread

• The Giants are hosting the Brewers and are favored by 1.5 runs (+146 to cover) on the runline. Milwaukee is -178 to cover.

Giants vs Brewers Over/Under

• The over/under for Giants-Brewers on April 21 is 8. The over is -110, and the under is -110.

Bet on San Francisco Giants vs. Milwaukee Brewers on FanDuel today!

Giants vs Brewers Betting Trends

• The Giants have been chosen as favorites in 11 games this year and have walked away with the win eight times (72.7%) in those games.
• San Francisco has a record of 2-2 when favored by -142 or more this year.
• The Giants and their opponents have hit the over in 14 of their 22 games with a total set by oddsmakers this season.
• In 22 games with a line this season, the Giants have a mark of 12-10-0 against the spread.
• The Brewers are 2-6 in games they were listed as the moneyline underdog (winning 25% of those games).
• In games it has played as a moneyline underdog with odds of +120 or longer, Milwaukee has a 1-5 record (winning only 16.7% of its games).
• The Brewers have played in 22 games with a set over/under, and have combined with their opponents to go over the total nine times (9-13-0).
• The Brewers are 12-10-0 against the spread this season.

Giants Player Leaders

• Jung Hoo Lee has 27 hits to go with a slugging percentage of .593, both of which are tops among San Francisco hitters this season. He has a .333 batting average and an on-base percentage of .389.
• Among qualified hitters in baseball, he ranks 10th in batting average, 27th in on-base percentage, and 12th in slugging.
• Matt James Chapman leads San Francisco in OBP (.406) this season, fueled by 18 hits. He's batting .240 while slugging .440.
• Among all qualifying hitters, he is 89th in batting average, 13th in on-base percentage and 61st in slugging percentage.
• Wilmer Flores has collected 16 base hits, an OBP of .250 and a slugging percentage of .430 this season.
• Mike Yastrzemski has been key for San Francisco with 17 hits, an OBP of .405 plus a slugging percentage of .525.

Brewers Player Leaders

• Jackson Chourio has racked up 25 hits, a team-high for the Brewers. He's batting .260 and slugging .521 with an on-base percentage of .273.
• He ranks 73rd in batting average, 137th in on-base percentage and 28th in slugging percentage among all qualified hitters in MLB.
• Brice Turang paces his team with a .437 slugging percentage. He has a batting average of .322 with an on-base percentage of .358.
• He is 15th in batting average, 48th in on-base percentage and 64th in slugging percentage in MLB.
• Sal Frelick has an on-base percentage of .432, a team-best for the Brewers.
• William Jesus (Castillo) Contreras has two doubles, three home runs and 13 walks while batting .230.

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