Reds vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 5:14 a.m.

The Monday slate in MLB includes a matchup between the Cincinnati Reds and the Miami Marlins.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Reds vs Marlins Game Info

• Cincinnati Reds (11-11) vs. Miami Marlins (9-12)
• Date: Monday, April 21, 2025
• Time: 6:40 p.m. ET
• Venue: loanDepot park -- Miami, Florida
• Coverage: FDSFL and FDSOH

Reds vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-126) | MIA: (+108)
• Spread: CIN: -1.5 (+130) | MIA: +1.5 (-156)
• Total: 8 -- Over: (-105) | Under: (-115)

Reds vs Marlins Probable Starting Pitchers

Probable Pitchers: Nick Lodolo (Reds) - 0-0, 0.00 ERA vs Max Meyer (Marlins) - 1-2, 2.63 ERA

The probable starters are Nick Lodolo for the Reds and Max Meyer (1-2) for the Marlins. Lodolo did not pitch as the moneyline favorite in any games last season. The Marlins are 2-2-0 ATS in Meyer's four starts with a set spread. The Marlins have a 1-2 record in Meyer's three starts this season when they were the moneyline underdog.

Reds vs Marlins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (55%)

Reds vs Marlins Moneyline

• The Reds vs Marlins moneyline has Cincinnati as a -126 favorite, while Miami is a +108 underdog at home.

Reds vs Marlins Spread

• The Reds are at the Marlins and are favored by 1.5 runs (+130 to cover) on the runline. Miami is -156 to cover.

Reds vs Marlins Over/Under

• The Reds-Marlins contest on April 21 has been given an over/under of 8 runs. The over is set at -105 and the under at -115.

Bet on Cincinnati Reds vs. Miami Marlins on FanDuel today!

Reds vs Marlins Betting Trends

• The Reds have been favorites in six games this season and have come away with the win four times (66.7%) in those contests.
• This season Cincinnati has come away with a win two times in four chances when named as a favorite of at least -126 on the moneyline.
• The Reds' games have gone over the total in 11 of their 22 opportunities.
• The Reds have posted a record of 13-9-0 against the spread this season.
• The Marlins have won 36.8% of the games this season they were the moneyline underdog (7-12).
• Miami has gone 6-11 when it has played as a moneyline underdog with odds of +108 or longer (35.3%).
• The Marlins have had an over/under set by bookmakers 21 times, and have combined with opponents to go over the total in 14 of those games (14-7-0).
• The Marlins are 11-10-0 against the spread this season.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in total hits (21) this season while batting .241 with eight extra-base hits. He has an on-base percentage of .313 and a slugging percentage of .448.
• Among the qualifying hitters in baseball, his batting average ranks 88th, his on-base percentage ranks 95th, and he is 57th in slugging.
• De La Cruz will look for his sixth straight game with a hit in this contest. In his last five games he is batting .300 with two home runs, four walks and four RBI.
• TJ Friedl leads Cincinnati in slugging percentage (.395) thanks to five extra-base hits. He's batting .296 with an on-base percentage of .363.
• Among all qualified hitters, he is 37th in batting average, 44th in on-base percentage and 92nd in slugging percentage.
• Friedl brings a four-game streak with at least one hit into this contest. In his last five games he is batting .409 with a double, a triple, four walks and four RBI.
• Matt McLain has 10 hits this season and has a slash line of .204/.339/.469.
• Gavin Lux has 22 hits this season and a team-best OBP of .427.
• Lux heads into this game on a six-game hitting streak. In his last 10 outings he is batting .455 with three doubles, nine walks and six RBI.

Marlins Player Leaders

• Otto Lopez is hitting .234 with five doubles, two home runs and nine walks. He's slugging .377 with an on-base percentage of .314.
• Including all qualifying hitters in MLB, his batting average places him 92nd, his on-base percentage is 91st, and he is 102nd in slugging.
• Xavier Edwards paces his team with a .333 slugging percentage. He has a batting average of .299 with an on-base percentage of .380.
• He is currently 34th in batting average, 33rd in on-base percentage and 129th in slugging percentage among all qualified hitters.
• Eric Wagaman is batting .267 with four doubles, two home runs and six walks.
• Kyle Stowers' .381 OBP leads his team.

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