Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 4:11 a.m.

The Thursday slate in MLB includes a matchup between the Detroit Tigers and the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Tigers vs Guardians Game Info

• Detroit Tigers (33-17) vs. Cleveland Guardians (26-22)
• Date: Thursday, May 22, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: MLB Network, FDSDET, and CLEG

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-136) | CLE: (+116)
• Spread: DET: -1.5 (+155) | CLE: +1.5 (-188)
• Total: 8 -- Over: (-105) | Under: (-115)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 2-5, 4.44 ERA vs Tanner Bibee (Guardians) - 3-4, 4.06 ERA

The probable pitchers are Jack Flaherty (2-5) for the Tigers and Tanner Bibee (3-4) for the Guardians. Flaherty and his team are 2-7-0 ATS this season when he starts. When Flaherty starts a game and his team is the favorite on the moneyline, they have a record of 2-3. The Guardians have a 3-5-0 record against the spread in Bibee's starts. The Guardians have been the underdog on the moneyline in three of Bibee's starts this season, and they went 1-2 in those games.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (61.9%)

Tigers vs Guardians Moneyline

• Cleveland is the underdog, +116 on the moneyline, while Detroit is a -136 favorite at home.

Tigers vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Tigers. The Guardians are -188 to cover the spread, and the Tigers are +155.

Tigers vs Guardians Over/Under

• A total of 8 runs has been set for the Tigers-Guardians contest on May 22, with the over available at -105 and the under at -115.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have been victorious in 21, or 75%, of the 28 contests they have been chosen as favorites in this season.
• This season Detroit has come away with a win 18 times in 20 chances when named as a favorite of at least -136 on the moneyline.
• The Tigers and their opponents have hit the over in 25 of their 49 games with a total set by oddsmakers this season.
• The Tigers are 27-22-0 against the spread in their 49 games with a line set by sportsbooks this season.
• The Guardians have a 13-14 record in games they were the underdog on the moneyline (winning 48.1% of those games).
• In games it has played as a moneyline underdog with odds of +116 or longer, Cleveland has a 4-6 record (winning 40% of its games).
• In the 46 games oddsmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 22 times (22-22-2).
• The Guardians have covered 45.7% of their games this season, going 21-25-0 ATS.

Tigers Player Leaders

• Spencer Torkelson has 43 hits, which is tops among Detroit hitters this season, while batting .249 with 25 extra-base hits. He has an on-base percentage of .357 and a slugging percentage of .532.
• He is 92nd in batting average, 46th in on-base percentage, and 17th in slugging among qualifying batters in MLB.
• Riley Greene leads Detroit in slugging percentage (.532) and total hits (54) this season. He's batting .287 with an on-base percentage of .343.
• His batting average ranks 33rd among qualified players, his on-base percentage 63rd, and his slugging percentage 17th.
• Greene has picked up a hit in four straight games. During his last five outings he is hitting .368 with two doubles, a home run, two walks and four RBIs.
• Gleyber Torres is batting .281 with a .432 slugging percentage and 24 RBI this year.
• Kerry Carpenter has 10 home runs, 22 RBI and a batting average of .278 this season.

Guardians Player Leaders

• Jose Ramirez leads the Guardians with 52 hits. He's batting .304 and slugging .520 with an on-base percentage of .363.
• Including all the qualifying hitters in MLB, his batting average puts him 18th, his on-base percentage is 39th, and he is 22nd in slugging.
• Ramirez heads into this game on a 14-game hitting streak. During his last 10 outings he is batting .395 with three doubles, three home runs, four walks and six RBIs.
• Steven Kwan's .377 on-base percentage and .439 slugging percentage both pace his team. He has a batting average of .317.
• He is seventh in batting average, 24th in on-base percentage and 62nd in slugging percentage in the big leagues.
• Carlos Santana is batting .231 with three doubles, six home runs and 24 walks.
• Kyle Manzardo is batting .216 with five doubles, two triples, 10 home runs and 19 walks.

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