Red Sox vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 4:12 a.m.

The Boston Red Sox will take on the Baltimore Orioles in MLB action on Thursday.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Orioles Game Info

• Boston Red Sox (25-26) vs. Baltimore Orioles (16-32)
• Date: Thursday, May 22, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: MLB Network, NESN, and MASN

Red Sox vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-120) | BAL: (+102)
• Spread: BOS: +1.5 (-200) | BAL: -1.5 (+162)
• Total: 9 -- Over: (-100) | Under: (-122)

Red Sox vs Orioles Probable Starting Pitchers

Probable Pitchers: Lucas Giolito (Red Sox) - 1-1, 7.08 ERA vs Cade Povich (Orioles) - 1-3, 5.23 ERA

The probable pitchers are Lucas Giolito (1-1) for the Red Sox and Cade Povich (1-3) for the Orioles. When Giolito starts, his team is 2-2-0 against the spread this season. Giolito's team is 1-1 this season when he starts and they're favored on the moneyline. The Orioles have gone 2-6-0 ATS in Povich's eight starts with a set spread. The Orioles have been the moneyline underdog in three of Povich's starts this season, and they went 1-2 in those matchups.

Red Sox vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (50.5%)

Red Sox vs Orioles Moneyline

• Baltimore is the underdog, +102 on the moneyline, while Boston is a -120 favorite at home.

Red Sox vs Orioles Spread

• The Orioles are 1.5-run favorites against the spread for this matchup with the Red Sox. The Orioles are +162 to cover, while the Red Sox are -200 to cover as a 1.5-run underdog on the runline.

Red Sox vs Orioles Over/Under

• Red Sox versus Orioles, on May 22, has an over/under of 9, with the over being -100 and the under -122.

Bet on Boston Red Sox vs. Baltimore Orioles on FanDuel today!

Red Sox vs Orioles Betting Trends

• The Red Sox have been favorites in 36 games this season and have come away with the win 18 times (50%) in those contests.
• This season Boston has come away with a win 13 times in 24 chances when named as a favorite of at least -120 on the moneyline.
• The Red Sox and their opponents have gone over the total this season in 24 of their 51 opportunities.
• The Red Sox are 26-25-0 against the spread in their 51 games that had a posted line this season.
• The Orioles have won seven of the 20 games they were listed as the moneyline underdog this season (35%).
• Baltimore has a 3-10 record (winning only 23.1% of its games) when it has played as a moneyline underdog of +102 or longer.
• The Orioles have played in 48 games with an over/under set, and have combined with opponents to go over the total 24 times (24-22-2).
• The Orioles have a 15-33-0 record ATS this season (covering just 31.2% of the time).

Red Sox Player Leaders

• Alex Bregman has 58 hits to go with a slugging percentage of .554, both of which are best among Boston hitters this season. He has a .297 batting average and an on-base percentage of .381.
• Among all qualified hitters, he ranks 22nd in batting average, his on-base percentage ranks 19th, and he is ninth in slugging.
• Rafael Devers leads Boston with an OBP of .409 this season while batting .287 with 39 walks and 31 runs scored. He's slugging .521.
• Among qualified batters, his batting average ranks him 33rd, his on-base percentage fifth, and his slugging percentage 21st.
• Devers brings a two-game streak with at least one hit into this one. During his last five outings he is batting .438 with two doubles, three home runs, five walks and seven RBIs.
• Wilyer Abreu is batting .257 with a .503 slugging percentage and 27 RBI this year.
• Jarren Duran has three home runs, 29 RBI and a batting average of .265 this season.

Orioles Player Leaders

• Cedric Mullins is hitting .236 with nine doubles, 10 home runs and 22 walks. He's slugging .473 with an on-base percentage of .332.
• Including all the qualifying hitters in the majors, his batting average places him 109th, his on-base percentage is 76th, and he is 46th in slugging.
• Mullins brings a four-game hitting streak into this game. During his last five outings he is batting .316 with two doubles, two home runs, a walk and six RBIs.
• Ryan O'Hearn has racked up 41 hits with a .396 OBP to lead his team in both. He has a batting average of .306 while slugging .507.
• Including all qualifying hitters, his batting average places him 13th, his on-base percentage ranks ninth, and he is 25th in slugging.
• Adley Rutschman is hitting .213 with seven doubles, a triple, five home runs and 19 walks.
• Jackson Holliday has four doubles, two triples, six home runs and 10 walks while hitting .268.

Red Sox vs Orioles Head to Head

• 4/3/2025: 8-4 BOS (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/2/2025: 3-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 3/31/2025: 8-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/11/2024: 5-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/10/2024: 5-3 BAL (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/9/2024: 12-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/18/2024: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/16/2024: 12-10 BOS (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/15/2024: 5-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/29/2024: 6-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)

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