Royals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 5:13 a.m.

The Sunday schedule in MLB includes a matchup between the Kansas City Royals and the San Diego Padres.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Royals vs Padres Game Info

• Kansas City Royals (38-39) vs. San Diego Padres (41-35)
• Date: Sunday, June 22, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSKC

Royals vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-112) | SD: (-104)
• Spread: KC: -1.5 (+146) | SD: +1.5 (-176)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Royals vs Padres Probable Starting Pitchers

Probable Pitchers: Seth Lugo (Royals) - 4-5, 3.05 ERA vs Randy Vasquez (Padres) - 3-4, 3.70 ERA

This contest's pitching matchup is set, as the Royals will send Seth Lugo (4-5) to the mound, while Randy Vasquez (3-4) will get the nod for the Padres. When Lugo starts, his team is 6-7-0 against the spread this season. Lugo's team has a record of 2-2 this season when he starts and they are the favorite on the moneyline. The Padres have a 7-7-0 record against the spread in Vasquez's starts. The Padres have a 3-7 record in Vasquez's 10 starts this season when they were the moneyline underdog.

Royals vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (53.4%)

Royals vs Padres Moneyline

• Looking at the moneyline for Padres-Royals, San Diego is the underdog at -104, and Kansas City is -112 playing on the road.

Royals vs Padres Spread

• The Padres are +1.5 on the spread (-176 to cover), and Kansas City is +146 to cover the runline.

Royals vs Padres Over/Under

• An over/under of 8.5 has been set for Royals-Padres on June 22, with the over being -100 and the under -122.

Bet on Kansas City Royals vs. San Diego Padres on FanDuel today!

Royals vs Padres Betting Trends

• The Royals have been favorites in 31 games this season and have come away with the win 15 times (48.4%) in those contests.
• This season Kansas City has been victorious 15 times in 31 chances when named as a favorite of at least -112 on the moneyline.
• Contests with the Royals have gone over the total set by sportsbooks in 30 of 77 chances this season.
• The Royals have an against the spread mark of 41-36-0 in 77 games with a line this season.
• The Padres have been the moneyline underdog 36 total times this season. They've finished 16-20 in those games.
• San Diego is 16-19 (winning 45.7% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Padres have had an over/under set by bookmakers 75 times, and have combined with opponents to go over the total in 32 of those games (32-41-2).
• The Padres have gone 41-34-0 against the spread this season.

Royals Player Leaders

• Bobby Witt Jr. is hitting .283 with 26 doubles, three triples, 10 home runs and 26 walks. He has an on-base percentage of .341 while slugging .490.
• Among the qualified hitters in baseball, his batting average ranks 30th, his on-base percentage ranks 60th, and he is 27th in slugging.
• Witt hopes to build on a six-game hitting streak in this matchup. During his last 10 games he is hitting .231 with four doubles, two home runs, three walks and three RBIs.
• Maikel Garcia leads Kansas City in OBP (.374), slugging percentage (.493) and total hits (87) this season. He's batting .315.
• He ranks eighth in batting average, 23rd in on-base percentage and 25th in slugging in MLB.
• Vinnie Pasquantino is batting .267 with a .411 slugging percentage and 41 RBI this year.
• Jonathan India is batting .242 with a .319 OBP and 22 RBI for Kansas City this season.

Padres Player Leaders

• Manny Machado has 89 hits with a .373 on-base percentage and a .503 slugging percentage, all club-bests for the Padres. He's batting .309.
• Including all qualifying hitters in the big leagues, his batting average places him 11th, his on-base percentage is 24th, and he is 21st in slugging.
• Fernando Tatis Jr. is batting .268 with 11 doubles, a triple, 14 home runs and 36 walks. He's slugging .461 with an on-base percentage of .357.
• Including all qualifying hitters, his batting average puts him 54th, his on-base percentage is 35th, and he is 52nd in slugging.
• Luis Arraez has 16 doubles, four triples, three home runs and 13 walks while hitting .280.
• Gavin Sheets has 11 doubles, a triple, 12 home runs and 20 walks while batting .265.

Royals vs Padres Head to Head

• 6/21/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/20/2025: 6-5 KC (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/2/2024: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/1/2024: 7-3 SD (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/31/2024: 11-8 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/17/2023: 4-3 KC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 5/16/2023: 5-4 KC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/15/2023: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/28/2022: 15-7 KC (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 8/27/2022: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)

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