Angels vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 4:12 a.m.

MLB action on Sunday includes the Los Angeles Angels playing the Houston Astros.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Angels vs Astros Game Info

• Los Angeles Angels (37-39) vs. Houston Astros (44-33)
• Date: Sunday, June 22, 2025
• Time: 4:07 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Angels vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAA: (-116) | HOU: (-102)
• Spread: LAA: +1.5 (-200) | HOU: -1.5 (+164)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Angels vs Astros Probable Starting Pitchers

Probable Pitchers: Kyle Hendricks (Angels) - 5-6, 4.79 ERA vs Ryan Gusto (Astros) - 4-3, 4.31 ERA

This contest's pitching matchup is set, as the Angels will send Kyle Hendricks (5-6) to the mound, while Ryan Gusto (4-3) will take the ball for the Astros. Hendricks' team is 7-7-0 against the spread in his starts this season. Hendricks' team is 1-1 this season when he starts and they're favored on the moneyline. When Gusto starts, the Astros have gone 4-6-0 against the spread. The Astros have not been the underdog on the moneyline when Gusto starts this season.

Angels vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (62.7%)

Angels vs Astros Moneyline

• Looking at the moneyline for Astros-Angels, Houston is the underdog at -102, and Los Angeles is -116 playing at home.

Angels vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Angels. The Astros are +164 to cover, while the Angels are -200 to cover as a 1.5-run underdog on the runline.

Angels vs Astros Over/Under

• Angels versus Astros on June 22 has an over/under of 8.5 runs, with the odds on the over -102 and the under set at -120.

Bet on Los Angeles Angels vs. Houston Astros on FanDuel today!

Angels vs Astros Betting Trends

• The Angels have been favorites in 15 games this season and have come away with the win nine times (60%) in those contests.
• This season Los Angeles has been victorious nine times in 14 chances when named as a favorite of at least -116 on the moneyline.
• The Angels and their opponents have hit the over in 38 of their 75 games with a total set by oddsmakers this season.
• The Angels have an against the spread mark of 39-36-0 in 75 games with a line this season.
• The Astros have won 56.5% of the games this season they were the moneyline underdog (13-10).
• Houston has gone 8-8 when it has played as a moneyline underdog with odds of -102 or longer (50%).
• The Astros have played in 76 games with a set over/under, and have combined with opponents to go over the total 30 times (30-44-2).
• The Astros have put together a 40-36-0 record ATS this season (covering 52.6% of the time).

Angels Player Leaders

• Nolan Schanuel leads Los Angeles OPS (.761) this season. He has a .277 batting average, an on-base percentage of .368, and a slugging percentage of .393.
• Among qualified hitters in baseball, his batting average ranks 42nd, his on-base percentage ranks 26th, and he is 115th in slugging.
• Taylor Ward is hitting .210 with 14 doubles, a triple, 19 home runs and 25 walks. He's slugging .465 with an on-base percentage of .271.
• He ranks 154th in batting average, 154th in on-base percentage and 45th in slugging among qualifying batters.
• Ward has picked up a hit in three games in a row. In his last five games he is batting .200 with a double, a home run, two walks and five RBIs.
• Zach Neto is batting .267 with a .466 slugging percentage and 26 RBI this year.
• Jo Adell leads Los Angeles in total hits (48) this season while batting .223 with 23 extra-base hits.
• Adell takes a four-game hitting streak into this game. In his last five games he is hitting .235 with three home runs, three walks and four RBIs.

Astros Player Leaders

• Jeremy Pena has accumulated 97 hits with a .380 on-base percentage and a .482 slugging percentage, all club-bests for the Astros. He's batting .324.
• Including all qualified hitters, he ranks sixth in batting average, while his on-base percentage is 18th and he is 32nd in slugging.
• Isaac Paredes has 10 doubles, a triple, 16 home runs and 41 walks while batting .254. He's slugging .474 with an on-base percentage of .359.
• Including all qualified hitters, his batting average puts him 88th, his on-base percentage ranks 33rd, and he is 40th in slugging.
• Jose Altuve is batting .269 with 10 doubles, 12 home runs and 24 walks.
• Jake Meyers is batting .307 with 13 doubles, a triple, three home runs and 23 walks.

Angels vs Astros Head to Head

• 6/21/2025: 9-1 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 14-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/22/2024: 9-8 LAA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 9/21/2024: 10-4 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 9/20/2024: 9-7 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 9/19/2024: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/15/2024: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -200, Underdog Moneyline: +168)

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