Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 4:12 a.m.

The Sunday slate in MLB includes a matchup between the Cleveland Guardians and the Athletics.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Athletics Game Info

• Cleveland Guardians (38-37) vs. Athletics (32-47)
• Date: Sunday, June 22, 2025
• Time: 4:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and CLEG

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-134) | OAK: (+114)
• Spread: CLE: -1.5 (+118) | OAK: +1.5 (-142)
• Total: 9.5 -- Over: (+102) | Under: (-124)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 2-3, 4.15 ERA vs JP Sears (Athletics) - 5-6, 5.45 ERA

The Guardians will call on Slade Cecconi (2-3) versus the Athletics and JP Sears (5-6). Cecconi's team is 4-2-0 against the spread this season in his starts. Cecconi's team is 1-1 this season when he starts and they're favored on the moneyline. The Athletics are 8-7-0 against the spread when Sears starts. The Athletics have a 2-7 record in Sears' nine starts this season when they were the underdog on the moneyline.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (53.6%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -134 favorite, while the Athletics are a +114 underdog at home.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +118 to cover, while the Athletics are -142 to cover.

Guardians vs Athletics Over/Under

• The Guardians-Athletics game on June 22 has been given an over/under of 9.5 runs. The over is set at +102 and the under at -124.

Bet on Cleveland Guardians vs. Athletics on FanDuel today!

Guardians vs Athletics Betting Trends

• The Guardians have been favorites in 25 games this season and have come away with the win 15 times (60%) in those contests.
• This season, the Guardians have come away with a win eight times in 11 chances when named as a favorite of at least -134 or shorter on the moneyline.
• The Guardians and their opponents have hit the over in 31 of their 73 games with a total this season.
• The Guardians have an against the spread record of 37-36-0 in 73 games with a line this season.
• The Athletics have compiled a 21-38 record in games they were listed as the moneyline underdog (winning 35.6% of those games).
• The Athletics have gone 11-31 in games they have played as a moneyline underdog with odds of +114 or longer (26.2%).
• The Athletics have played in 79 games with an over/under set, and have combined with their opponents to go over the total 43 times (43-33-3).
• The Athletics have a 38-41-0 record against the spread this season (covering 48.1% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland in OBP (.385), slugging percentage (.531) and total hits (89) this season. He has a .324 batting average.
• Among all qualifying hitters in MLB, he is sixth in batting average, 13th in on-base percentage, and 11th in slugging.
• Ramirez will look for his fifth straight game with a hit in this matchup. During his last five outings he is batting .316 with a double, two walks and two RBIs.
• Steven Kwan is hitting .305 with 17 doubles, six home runs and 25 walks, while slugging .430 with an on-base percentage of .366.
• Among qualifying hitters, he ranks 13th in batting average, 30th in on-base percentage and 79th in slugging percentage.
• Kwan has picked up at least one hit in three straight games. In his last five games he is hitting .368 with three doubles, two walks and an RBI.
• Carlos Santana has collected 59 base hits, an OBP of .329 and a slugging percentage of .356 this season.
• Kyle Manzardo has 11 home runs, 31 RBI and a batting average of .217 this season.

Athletics Player Leaders

• Jacob Wilson has accumulated 102 hits with a .392 on-base percentage and a .498 slugging percentage, all club-bests for the Athletics. He's batting .353.
• Including all the qualifying players in the big leagues, his batting average places him second, his on-base percentage ranks ninth, and he is 22nd in slugging.
• Brent Rooker is hitting .272 with 16 doubles, two triples, 15 home runs and 35 walks. He's slugging .482 with an on-base percentage of .350.
• He is currently 46th in batting average, 50th in on-base percentage and 32nd in slugging percentage among all qualified batters.
• Tyler Soderstrom is batting .249 with 11 doubles, a triple, 14 home runs and 33 walks.
• Lawrence Butler has 23 doubles, a triple, 11 home runs and 27 walks while batting .261.

Guardians vs Athletics Head to Head

• 6/21/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/21/2024: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/20/2024: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/19/2024: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 3/31/2024: 4-3 OAK (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/30/2024: 12-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/29/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/28/2024: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/22/2023: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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