Red Sox vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 1:12 a.m.

The MLB's Friday slate includes the Boston Red Sox facing the Minnesota Twins.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Twins Game Info

• Boston Red Sox (22-27) vs. Minnesota Twins (23-27)
• Date: Friday, May 22, 2026
• Time: 7:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and Twins.TV

Red Sox vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-154) | MIN: (+130)
• Spread: BOS: -1.5 (+146) | MIN: +1.5 (-176)
• Total: 8 -- Over: (-104) | Under: (-118)

Red Sox vs Twins Probable Starting Pitchers

Probable Pitchers: Payton Tolle (Red Sox) - 2-2, 2.05 ERA vs Connor Prielipp (Twins) - 1-2, 2.88 ERA

This contest's pitching matchup is set, as the Red Sox will send Payton Tolle (2-2) to the mound, while Connor Prielipp (1-2) will get the nod for the Twins. Tolle and his team are 1-4-0 ATS this season when he starts. Tolle's team is 1-1 this season when he starts and they're favored on the moneyline. The Twins have a 3-2-0 ATS record in Prielipp's five starts that had a set spread. The Twins have a 1-4 record in Prielipp's five starts this season when they were the underdog on the moneyline.

Red Sox vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (54.5%)

Red Sox vs Twins Moneyline

• Boston is the favorite, -154 on the moneyline, while Minnesota is a +130 underdog on the road.

Red Sox vs Twins Spread

• The Twins are +1.5 on the spread (-176 to cover), and Boston is +146 to cover the runline.

Red Sox vs Twins Over/Under

• The Red Sox-Twins game on May 22 has been given an over/under of 8 runs. The over is set at -104 and the under at -118.

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Red Sox vs Twins Betting Trends

• The Red Sox have been chosen as favorites in 31 games this year and have walked away with the win 15 times (48.4%) in those games.
• This season Boston has come away with a win two times in five chances when named as a favorite of at least -154 on the moneyline.
• The Red Sox and their opponents have gone over in 21 of their 49 games with a total set by sportsbooks this season.
• The Red Sox are 20-29-0 against the spread in their 49 games that had a posted line this season.
• The Twins have won 43.8% of the games this season they were the underdog on the moneyline (14-18).
• When it has played as a moneyline underdog with odds of +130 or longer, Minnesota has a record of 5-2 (71.4%).
• The Twins have played in 49 games with a set over/under, and have combined with their opponents to go over the total 29 times (29-19-1).
• The Twins have a 26-23-0 record against the spread this season (covering 53.1% of the time).

Red Sox Player Leaders

• Wilyer Abreu leads Boston in slugging percentage (.438) thanks to 14 extra-base hits. He has a .292 batting average and an on-base percentage of .359.
• Among all qualified batters in baseball, he ranks 21st in batting average, 43rd in on-base percentage, and 61st in slugging.
• Abreu has hit safely in two straight games. In his last five games he is batting .217 with a double.
• Willson Contreras has 45 hits and an OBP of .369, both of which lead the Red Sox this season. He's batting .269 and slugging .497.
• Among qualifying hitters, his batting average places him 52nd, his on-base percentage 31st, and his slugging percentage 26th.
• Contreras brings a five-game streak with at least one hit into this one. During his last five outings he is batting .450 with a double, a triple, two home runs and seven RBIs.
• Jarren Duran has 34 hits this season and has a slash line of .195/.266/.362.
• Duran brings a two-game hitting streak into this game. In his last five games he is hitting .368 with three doubles, a triple, two home runs, four walks and six RBIs.
• Ceddanne Rafaela is batting .287 with a .353 OBP and 19 RBI for Boston this season.
• Rafaela takes a five-game hitting streak into this game. During his last five outings he is batting .368 with four doubles and two walks.

Twins Player Leaders

• Byron Buxton has racked up a team-high OBP (.320) and slugging percentage (.576), and paces the Twins in hits (46, while batting .260).
• Including all qualified hitters, he ranks 71st in batting average, while his on-base percentage ranks 98th and he is sixth in slugging.
• Brooks Lee is batting .248 with six doubles, a triple, five home runs and 11 walks. He's slugging .388 with an on-base percentage of .299.
• Including all qualified players, he ranks 90th in batting average, 129th in on-base percentage and 99th in slugging percentage.
• Luke Keaschall is hitting .227 with eight doubles, a triple, a home run and 19 walks.
• Josh Bell is batting .231 with eight doubles, five home runs and 15 walks.

Red Sox vs Twins Head to Head

• 4/15/2026: 9-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/14/2026: 6-0 MIN (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/13/2026: 13-6 MIN (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 7/30/2025: 13-1 BOS (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/29/2025: 8-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/28/2025: 5-4 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/4/2025: 5-4 MIN (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/3/2025: 4-3 MIN (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/2/2025: 6-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/22/2024: 9-3 BOS (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)

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