Phillies vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 1:12 a.m.

The MLB's Friday schedule includes the Philadelphia Phillies taking on the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Phillies vs Guardians Game Info

• Philadelphia Phillies (25-25) vs. Cleveland Guardians (30-22)
• Date: Friday, May 22, 2026
• Time: 6:40 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and CleGuardians.TV

Phillies vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-184) | CLE: (+154)
• Spread: PHI: -1.5 (+118) | CLE: +1.5 (-142)
• Total: 7 -- Over: (-110) | Under: (-110)

Phillies vs Guardians Probable Starting Pitchers

Probable Pitchers: Cristopher Sanchez (Phillies) - 5-2, 1.82 ERA vs Gavin Williams (Guardians) - 6-3, 3.67 ERA

This contest's pitching matchup is set, as the Phillies will send Cristopher Sanchez (5-2) to the mound, while Gavin Williams (6-3) will get the nod for the Guardians. When Sanchez starts, his team is 5-5-0 against the spread this season. Sanchez's team has been victorious in 70% of the games he's started as the moneyline favorite with a record of 7-3. The Guardians have a 6-3-0 ATS record in Williams' nine starts with a set spread. The Guardians were the moneyline underdog for two Williams starts this season -- they split the games.

Phillies vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (65.9%)

Phillies vs Guardians Moneyline

• Cleveland is the underdog, +154 on the moneyline, while Philadelphia is a -184 favorite at home.

Phillies vs Guardians Spread

• The Phillies are favored by 1.5 runs at home versus the Guardians. The Phillies are +118 to cover the spread, while the Guardians are -142.

Phillies vs Guardians Over/Under

• The over/under for the Phillies versus Guardians contest on May 22 has been set at 7, with -110 odds on the over and -110 odds on the under.

Bet on Philadelphia Phillies vs. Cleveland Guardians on FanDuel today!

Phillies vs Guardians Betting Trends

• The Phillies have come away with 20 wins in the 36 contests they have been listed as the favorites in this season.
• This season Philadelphia has come away with a win eight times in nine chances when named as a favorite of at least -184 on the moneyline.
• The Phillies and their opponents have hit the over in 24 of their 50 games with a total set by oddsmakers this season.
• In 50 games with a line this season, the Phillies have a mark of 15-35-0 against the spread.
• The Guardians have won 54.5% of the games this season they were the moneyline underdog (12-10).
• When playing as a moneyline underdog with odds of +154 or longer, Cleveland has a 2-2 record (winning 50% of its games).
• In the 49 games oddsmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 25 times (25-24-0).
• The Guardians have put together a 26-23-0 record against the spread this season (covering 53.1% of the time).

Phillies Player Leaders

• Bryce Harper leads Philadelphia in OBP (.359) this season, fueled by 48 hits. He has a .267 batting average and a slugging percentage of .528.
• Among qualifying batters in baseball, he ranks 59th in batting average, 43rd in on-base percentage, and 17th in slugging.
• Kyle Schwarber leads Philadelphia with 41 hits. He is batting .230 this season and has 29 extra-base hits. He's also slugging .624 with an on-base percentage of .357.
• He is 120th in batting average, 48th in on-base percentage and second in slugging among qualifying hitters.
• Trea Turner has 48 hits this season and has a slash line of .239/.294/.358.
• Turner brings a seven-game hitting streak into this matchup. In his last 10 outings he is hitting .216 with two doubles, a home run, four walks and four RBIs.
• Brandon Marsh leads Philadelphia with a slugging percentage of .464, fueled by 14 extra-base hits.

Guardians Player Leaders

• Jose Ramirez is batting .236 with 11 doubles, eight home runs and 37 walks. He's slugging .419 with an on-base percentage of .361.
• Including all qualifying hitters, he is 112th in batting average, while his on-base percentage is 39th and he is 78th in slugging.
• Chase DeLauter is hitting .267 with 10 doubles, a triple, seven home runs and 24 walks. He's slugging .459 with an on-base percentage of .354.
• Including all qualifying hitters, his batting average puts him 59th, his on-base percentage is 52nd, and he is 49th in slugging.
• Brayan Rocchio has a .376 on-base percentage and a .420 slugging percentage, both team-best numbers for the Guardians.
• Angel Martinez paces his team with 41 hits.

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