Red Sox vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 4:17 a.m.

On Tuesday in MLB, the Boston Red Sox are up against the Seattle Mariners.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Mariners Game Info

• Boston Red Sox (13-11) vs. Seattle Mariners (12-10)
• Date: Tuesday, April 22, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and ROOT Sports NW

Red Sox vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-134) | SEA: (+114)
• Spread: BOS: -1.5 (+150) | SEA: +1.5 (-182)
• Total: 9 -- Over: (-110) | Under: (-110)

Red Sox vs Mariners Probable Starting Pitchers

Probable Pitchers: Brayan Bello (Red Sox) - 0-0, 0.00 ERA vs Bryce Miller (Mariners) - 1-2, 3.43 ERA

This contest's pitching matchup is set, as the Red Sox will send Brayan Bello to the mound, while Bryce Miller (1-2) will take the ball for the Mariners. Bello and his team were 15-14-0 against the spread when he pitched last season. Bello and his team won as favorites in 64.3% of his 14 appearances last season with a moneyline. The Mariners have gone 2-2-0 ATS in Miller's four starts that had a set spread. The Mariners were named the moneyline underdog for two Miller starts this season -- they split the games.

Red Sox vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (58.8%)

Red Sox vs Mariners Moneyline

• Boston is the favorite, -134 on the moneyline, while Seattle is a +114 underdog on the road.

Red Sox vs Mariners Spread

• The Red Sox are 1.5-run home favorites on the runline against the Mariners. The Red Sox are +150 to cover, and the Mariners are -182.

Red Sox vs Mariners Over/Under

• The Red Sox-Mariners contest on April 22 has been given an over/under of 9 runs. The over is set at -110 and the under at -110.

Bet on Boston Red Sox vs. Seattle Mariners on FanDuel today!

Red Sox vs Mariners Betting Trends

• The Red Sox have come away with 10 wins in the 17 contests they have been listed as the favorites in this season.
• This season Boston has been victorious four times in eight chances when named as a favorite of at least -134 on the moneyline.
• The Red Sox's games have gone over the total in nine of their 24 opportunities.
• The Red Sox have posted a record of 12-12-0 against the spread this season.
• The Mariners have a 4-4 record in games they were the underdog on the moneyline (winning 50% of those games).
• Seattle has played as a moneyline underdog of +114 or longer in only two games this season, which it split 1-1.
• The Mariners have combined with opponents to hit the over on the total 10 times this season for a 10-10-2 record against the over/under.
• The Mariners are 11-11-0 against the spread this season.

Red Sox Player Leaders

• Alexander David Bregman is batting .297 with seven doubles, four home runs and nine walks. He has an on-base percentage of .375 and a slugging percentage of .505.
• Among all qualified batters, he ranks 34th in batting average, his on-base percentage ranks 34th, and he is 34th in slugging.
• Bregman hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .389 with a double, two home runs, five walks and four RBI.
• Wilyer Abreu has five doubles, four home runs and 15 walks. He's batting .274 and slugging .507 with an on-base percentage of .398.
• Among qualified hitters, his batting average places him 61st, his on-base percentage 19th, and his slugging percentage 32nd.
• Trevor Story has a team-high 30 hits to go with a slugging percentage of .528.
• Story brings a three-game hitting streak into this game. In his last five games he is hitting .450 with two home runs, a walk and seven RBI.
• Kristian Campbell leads Boston with an OBP of .418 this season while batting .316 with 14 walks and 11 runs scored.
• Campbell has hit safely in three games in a row. In his last five games he is batting .278 with a double, four walks and two RBI.

Mariners Player Leaders

• Cal Raleigh has racked up a team-best slugging percentage (.593) and paces the Mariners in hits (20). He's batting .233 and with an on-base percentage of .333.
• Including all qualified hitters in MLB, he is 96th in batting average, 78th in on-base percentage and 12th in slugging percentage.
• Raleigh hopes to build on a five-game hitting streak in this matchup. During his last five outings he is batting .318 with a double, four home runs, four walks and seven RBI.
• Randy Arozarena has six doubles, four home runs and 16 walks while hitting .200. He's slugging .425 with an on-base percentage of .354.
• Including all qualifying players, he ranks 135th in batting average, 53rd in on-base percentage and 74th in slugging percentage.
• Dylan Moore has a double, five home runs and five walks while hitting .316.
• Julio Rodriguez is batting .188 with two doubles, two triples, three home runs and 12 walks.

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