Rays vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 8:11 a.m.

The Friday schedule in MLB includes a matchup between the Tampa Bay Rays and the St. Louis Cardinals.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Rays vs Cardinals Game Info

• Tampa Bay Rays (61-67) vs. St. Louis Cardinals (64-65)
• Date: Friday, August 22, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and FDSMW

Rays vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-134) | STL: (+114)
• Spread: TB: -1.5 (+160) | STL: +1.5 (-194)
• Total: 9 -- Over: (-110) | Under: (-110)

Rays vs Cardinals Probable Starting Pitchers

Probable Pitchers: Adrian Houser (Rays) - 6-4, 2.67 ERA vs Miles Mikolas (Cardinals) - 6-9, 4.99 ERA

The Rays will give the nod to Adrian Houser (6-4) versus the Cardinals and Miles Mikolas (6-9). Houser's team is 8-5-0 against the spread this season in his starts. Houser's team is 2-0 this season when he starts and they're favored on the moneyline. When Mikolas starts, the Cardinals are 10-14-0 against the spread. The Cardinals are 7-10 in Mikolas' 17 starts this season that they were the moneyline underdog.

Rays vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (59.9%)

Rays vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Rays, St. Louis is the underdog at +114, and Tampa Bay is -134 playing at home.

Rays vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-194 to cover), and Tampa Bay is +160 to cover the runline.

Rays vs Cardinals Over/Under

• The over/under for the Rays versus Cardinals game on Aug. 22 has been set at 9, with -110 odds on the over and -110 odds on the under.

Bet on Tampa Bay Rays vs. St. Louis Cardinals on FanDuel today!

Rays vs Cardinals Betting Trends

• The Rays have come away with 33 wins in the 57 contests they have been listed as the favorites in this season.
• This year Tampa Bay has won 16 of 30 games when listed as at least -134 on the moneyline.
• The Rays and their opponents have gone over in 52 of their 124 games with a total set by sportsbooks this season.
• The Rays have an against the spread mark of 52-72-0 in 124 games with a line this season.
• The Cardinals have gone 33-35 in games they were the underdog on the moneyline (winning 48.5% of those games).
• When it has played as a moneyline underdog with odds of +114 or longer, St. Louis has a 16-22 record (winning 42.1% of its games).
• The Cardinals have combined with opponents to go over the total 64 times this season for a 64-55-5 record against the over/under.
• The Cardinals have a 64-60-0 record ATS this season (covering 51.6% of the time).

Rays Player Leaders

• Junior Caminero has 122 hits, which is tops among Tampa Bay hitters this season, while batting .255 with 56 extra-base hits. He has an on-base percentage of .298 and a slugging percentage of .519.
• Among all qualifying batters, he ranks 88th in batting average, his on-base percentage ranks 136th, and he is 13th in slugging.
• Caminero hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .105 with three walks and an RBI.
• Yandy Diaz leads Tampa Bay in slugging percentage (.463) thanks to 44 extra-base hits. He's batting .281 with an on-base percentage of .341.
• His batting average ranks 27th among qualified players, his on-base percentage 52nd, and his slugging percentage 53rd.
• Brandon Lowe has 106 hits this season and has a slash line of .269/.321/.485.
• Chandler Simpson has no home runs, but 19 RBI and a batting average of .302 this season.
• Simpson enters this game on a three-game hitting streak. During his last five outings he is batting .238 with a double, two walks and an RBI.

Cardinals Player Leaders

• Alec Burleson is hitting .285 with 20 doubles, a triple, 15 home runs and 33 walks. He's slugging .449 with an on-base percentage of .337.
• Including all the qualifying players in MLB, he is 23rd in batting average, 60th in on-base percentage and 65th in slugging percentage.
• Willson Contreras' 112 hits pace his team. He has a batting average of .261 while slugging .455 with an on-base percentage of .345.
• His batting average ranks 70th among all qualified players, his on-base percentage ranks 49th, and he is 60th in slugging.
• Masyn Winn has 26 doubles, nine home runs and 31 walks while batting .260.
• Lars Nootbaar is batting .244 with 20 doubles, 13 home runs and 50 walks.

Rays vs Cardinals Head to Head

• 8/21/2025: 7-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/8/2024: 6-4 TB (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/7/2024: 5-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/6/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/10/2023: 5-2 STL (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 8/9/2023: 6-4 STL (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/8/2023: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/9/2022: 2-1 TB (Favorite: Rays, Spread: -1.5, Total: 6.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/8/2022: 11-3 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/7/2022: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)

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