Pirates vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 1:12 a.m.

On Wednesday in MLB, the Pittsburgh Pirates are playing the Chicago Cubs.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Pirates vs Cubs Game Info

• Pittsburgh Pirates (29-26) vs. Chicago Cubs (29-26)
• Date: Wednesday, May 27, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and MARQ

Pirates vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-112) | CHC: (-104)
• Spread: PIT: +1.5 (-188) | CHC: -1.5 (+155)
• Total: 8.5 -- Over: (-124) | Under: (+102)

Pirates vs Cubs Probable Starting Pitchers

Probable Pitchers: Bubba Chandler (Pirates) - 1-6, 4.79 ERA vs Jameson Taillon (Cubs) - 2-4, 5.20 ERA

The probable starters are Bubba Chandler (1-6) for the Pirates and Jameson Taillon (2-4) for the Cubs. When Chandler starts, his team is 4-6-0 against the spread this season. When Chandler starts a game and his team is the favorite on the moneyline, they have a record of 2-2. The Cubs have a 2-8-0 ATS record in Taillon's 10 starts that had a set spread. The Cubs have a 2-2 record in Taillon's four starts this season when they were the moneyline underdog.

Pirates vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (55%)

Pirates vs Cubs Moneyline

• Chicago is the underdog, -104 on the moneyline, while Pittsburgh is a -112 favorite at home.

Pirates vs Cubs Spread

• The Cubs are 1.5-run favorites against the spread for this matchup with the Pirates. The Cubs are +155 to cover, while the Pirates are -188 to cover as a 1.5-run underdog on the runline.

Pirates vs Cubs Over/Under

• An over/under of 8.5 has been set for Pirates-Cubs on May 27, with the over being -124 and the under +102.

Bet on Pittsburgh Pirates vs. Chicago Cubs on FanDuel today!

Pirates vs Cubs Betting Trends

• The Pirates have been victorious in 19, or 61.3%, of the 31 contests they have been chosen as favorites in this season.
• Pittsburgh has a record of 17-12 in contests when oddsmakers favor them by -112 or more on the moneyline.
• Contests with the Pirates have gone over the total set by oddsmakers in 27 of 54 chances this season.
• The Pirates have an against the spread record of 28-26-0 in 54 games with a line this season.
• The Cubs have gone 8-9 in games they were listed as the moneyline underdog (winning 47.1% of those games).
• In games it has played as a moneyline underdog with odds of -104 or longer, Chicago has a record of 6-9 (40%).
• In the 54 games oddsmakers have set an over/under for the Cubs, they have combined with opponents to go over the total 30 times (30-24-0).
• The Cubs have a 21-33-0 record against the spread this season (covering just 38.9% of the time).

Pirates Player Leaders

• Brandon Lowe has 51 hits, which is best among Pittsburgh hitters this season, while batting .270 with 26 extra-base hits. He has an on-base percentage of .356 and a slugging percentage of .550.
• Among all qualified hitters in MLB, his batting average ranks 48th, his on-base percentage ranks 47th, and he is 12th in slugging.
• Lowe hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .412 with a double, a walk and an RBI.
• Bryan Reynolds is hitting .256 with 10 doubles, two triples, four home runs and 36 walks. He's slugging .390 with an on-base percentage of .379.
• He ranks 76th in batting average, 23rd in on-base percentage and 92nd in slugging among qualified batters.
• Reynolds heads into this matchup looking to extend his four-game hit streak. In his last five games he is batting .400 with two doubles, two walks and three RBIs.
• Oneil Cruz leads Pittsburgh in slugging percentage (.461) powered by 21 extra-base hits.
• Cruz takes a three-game hitting streak into this game. During his last five outings he is batting .353 with a home run and two RBIs.
• Spencer Horwitz has 44 hits this season and a team-best OBP of .391.
• Horwitz brings a four-game hitting streak into this game. During his last five outings he is hitting .400 with two home runs, two walks and four RBIs.

Cubs Player Leaders

• Nico Hoerner is batting .252 with 13 doubles, four home runs and 25 walks. He's slugging .369 with an on-base percentage of .337.
• Including all the qualifying hitters in the majors, his batting average ranks 81st, his on-base percentage is 74th, and he is 113th in slugging.
• Michael Busch leads his team with a .359 on-base percentage. He has a batting average of .231 while slugging .390.
• He is currently 115th in batting average, 41st in on-base percentage and 92nd in slugging percentage among all qualified hitters.
• Alex Bregman has a .356 slugging percentage, which leads the Cubs.
• Ian Happ leads his team with 40 hits.

Pirates vs Cubs Head to Head

• 5/26/2026: 12-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/25/2026: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/12/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 12.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/11/2026: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/10/2026: 2-0 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/17/2025: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/16/2025: 4-1 CHC (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/15/2025: 4-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/17/2025: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/16/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!