Phillies vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 12:12 a.m.

The Wednesday slate in MLB includes a matchup between the Philadelphia Phillies and the San Diego Padres.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Phillies vs Padres Game Info

• Philadelphia Phillies (27-27) vs. San Diego Padres (31-22)
• Date: Wednesday, May 27, 2026
• Time: 4:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and NBCS-PH

Phillies vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-154) | SD: (+130)
• Spread: PHI: -1.5 (+114) | SD: +1.5 (-137)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Phillies vs Padres Probable Starting Pitchers

Probable Pitchers: Cristopher Sanchez (Phillies) - 5-2, 1.62 ERA vs Walker Buehler (Padres) - 3-2, 5.05 ERA

The Phillies will give the ball to Cristopher Sanchez (5-2, 1.62 ERA), who is eyeing win No. 6 on the season, and the Padres will counter with Walker Buehler (3-2, 5.05 ERA). When Sanchez starts, his team is 5-6-0 against the spread this season. Sanchez's team has a record of 7-4 this season when he starts and they are the favorite on the moneyline. The Padres are 7-3-0 against the spread when Buehler starts. The Padres are 4-1 in Buehler's five starts this season that they were the underdog on the moneyline.

Phillies vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (55.2%)

Phillies vs Padres Moneyline

• San Diego is the underdog, +130 on the moneyline, while Philadelphia is a -154 favorite despite being on the road.

Phillies vs Padres Spread

• The Phillies are at the Padres and are favored by 1.5 runs (+114 to cover) on the runline. San Diego is -137 to cover.

Phillies vs Padres Over/Under

• The Phillies-Padres game on May 27 has been given an over/under of 7.5 runs. The over is set at -104 and the under at -118.

Bet on Philadelphia Phillies vs. San Diego Padres on FanDuel today!

Phillies vs Padres Betting Trends

• The Phillies have been chosen as favorites in 38 games this year and have walked away with the win 21 times (55.3%) in those games.
• This year Philadelphia has won 12 of 19 games when listed as at least -154 on the moneyline.
• Contests with the Phillies have gone over the total set by sportsbooks in 24 of 53 chances this season.
• In 53 games with a line this season, the Phillies have a mark of 16-37-0 against the spread.
• The Padres have won 54.2% of the games this season they were the moneyline underdog (13-11).
• When it has played as a moneyline underdog with odds of +130 or longer, San Diego has gone 2-2 (50%).
• The Padres have had an over/under set by oddsmakers 53 times, and have combined with opponents to go over the total in 22 of those games (22-30-1).
• The Padres have collected a 30-23-0 record ATS this season.

Phillies Player Leaders

• Bryce Harper has 52 hits this season and a team-best OBP of .360. He has a .269 batting average and a slugging percentage of .518.
• Among all qualified hitters in the majors, his batting average ranks 51st, his on-base percentage ranks 37th, and he is 19th in slugging.
• Kyle Schwarber leads Philadelphia with 45 hits. He is batting .233 this season and has 31 extra-base hits. He's also slugging .617 with an on-base percentage of .354.
• Among qualifying hitters, his batting average places him 112th, his on-base percentage 48th, and his slugging percentage second.
• Schwarber has picked up at least one hit in two straight games. During his last five outings he is batting .200 with a double, a home run, a walk and an RBI.
• Brandon Marsh leads Philadelphia in slugging percentage (.475) powered by 16 extra-base hits.
• Marsh brings a two-game hitting streak into this game. During his last five outings he is hitting .294 with a triple, a home run, two walks and two RBIs.
• Bryson Stott is batting .236 with a .287 OBP and 25 RBI for Philadelphia this season.

Padres Player Leaders

• Xander Bogaerts paces the Padres with 45 hits. He's batting .245 and slugging .375 with an on-base percentage of .314.
• Including all qualifying hitters in MLB, he ranks 88th in batting average, 108th in on-base percentage and 109th in slugging percentage.
• Gavin Sheets is batting .253 with 10 doubles, nine home runs and 16 walks. He's slugging .507 with an on-base percentage of .331.
• Miguel Andujar has 12 doubles, two triples, five home runs and five walks while hitting .281.
• Manny Machado is hitting .170 with five doubles, eight home runs and 25 walks.

Phillies vs Padres Head to Head

• 5/25/2026: 3-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 7/13/2025: 2-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/12/2025: 5-4 SD (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 7/11/2025: 4-2 SD (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/2/2025: 5-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/2/2025: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/30/2025: 4-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 6/19/2024: 5-2 SD (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/18/2024: 4-3 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/17/2024: 9-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!