Penn State vs USC Prediction, Odds, Picks, Best Bets for Week 6 2026

Saturday's slate in college football includes a matchup between the Penn State Nittany Lions and the USC Trojans.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Penn State vs USC Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Penn State: (-118) | USC: (+100)
• Spread: Penn State: -1.5 (-106) | USC: +1.5 (-114)
• Total: 54.5 -- Over: (-118) | Under: (-104)

Penn State vs USC Betting Trends

• Penn State has won twice against the spread this season.
• Penn State has won twice ATS (2-3) as a 1.5-point or bigger favorite this year.
• There have been three Penn State games (of five) that hit the over this year.
• USC has one win against the spread this year.
• USC doesn't have a win ATS (0-1) as a 1.5-point underdog or more this year.
• There have been four USC games (out of six) that went over the total this season.

Penn State vs USC Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (72.1%)

Penn State vs USC Point Spread

USC is a 1.5-point underdog against Penn State. USC is -114 to cover the spread, and Penn State is -106.

Penn State vs USC Over/Under

A combined point total of 54.5 has been set for Penn State-USC on Oct. 10, with the over at -118 and the under at -104.

Penn State vs USC Moneyline

Looking at the moneyline for Penn State-USC, Penn State is the favorite at -118, and USC is +100.

Penn State vs. USC Points Insights

Penn State vs. USC Game Info

• Game day: Saturday, October 10, 2026
• Game time: 7:30 p.m. ET
• TV channel: NBC/Peacock
• Location: University Park, Pennsylvania
• Stadium: West Shore Home Field at Beaver Stadium

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Check out even more in-depth Penn State vs. USC analysis on FanDuel Research.