NFL Games This Sunday: Predictions, Odds, Picks, Best Bets for Week 5

In one of the many exciting matchups on Sunday in the NFL in Week 5, the San Francisco 49ers and the Seattle Seahawks take the field at Lumen Field.

Read through our odds breakdown for the NFL's Week 5 action on Sunday.

Jaguars vs. Eagles

The Jacksonville Jaguars (3-1) will take on the Philadelphia Eagles (2-2) on Sunday at 9:30 a.m. ET.

• Game Preview: Philadelphia Eagles vs. Jacksonville Jaguars
• Projected Favorite: Jaguars (73.30% win probability)
• Spread: Jacksonville (-7.5)
• Total: 41.5 -- Over: (-115) | Under: (-105)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Jacksonville vs. Philadelphia with FanDuel Sportsbook.

Steelers vs. Colts

Star running back Jonathan Taylor and the Indianapolis Colts (2-2) play the Pittsburgh Steelers (2-2) on Sunday at 1 p.m. ET, at Acrisure Stadium.

• Game Preview: Indianapolis Colts at Pittsburgh Steelers
• Projected Favorite: Colts (56.37% win probability)
• Spread: Pittsburgh (-2.5)
• Total: 44.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Pittsburgh vs. Indianapolis with FanDuel Sportsbook.

Dolphins vs. Bengals

The Cincinnati Bengals (2-2), who were defeated by the Jaguars in their last contest, visit the Miami Dolphins (0-4) at Hard Rock Stadium on Oct. 11 at 1 p.m. ET. The Dolphins lost to the Vikings in their last game.

• Game Preview: Cincinnati Bengals at Miami Dolphins
• Projected Favorite: Bengals (58.80% win probability)
• Spread: Cincinnati (-6.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Miami vs. Cincinnati with FanDuel Sportsbook.

Jets vs. Browns

On Sunday, Oct. 11 at 1 p.m. ET, the New York Jets (1-3) will attempt to rebound from their recent 23-12 loss to the Bears when they square off against the Cleveland Browns (3-1) at MetLife Stadium. The Browns won their previous game 27-24 against the Steelers.

• Game Preview: Cleveland Browns at New York Jets
• Projected Favorite: Jets (56.93% win probability)
• Spread: New York (-1.5)
• Total: 40.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Cleveland with FanDuel Sportsbook.

Titans vs. Texans

The Houston Texans (0-4) will visit the Tennessee Titans (0-4) on Sunday at 1 p.m. ET.

• Game Preview: Houston Texans at Tennessee Titans
• Projected Favorite: Texans (72.07% win probability)
• Spread: Houston (-7.5)
• Total: 37.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tennessee vs. Houston with FanDuel Sportsbook.

Saints vs. Vikings

The Minnesota Vikings (4-0), who defeated the Dolphins in their last game, visit the New Orleans Saints (1-3) at Caesars Superdome on Oct. 11 at 1 p.m. ET. The Saints were defeated by the Falcons in their last game.

• Game Preview: Minnesota Vikings at New Orleans Saints
• Projected Favorite: Vikings (51.33% win probability)
• Spread: Minnesota (-1.5)
• Total: 42.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Minnesota with FanDuel Sportsbook.

Commanders vs. Giants

On Sunday at 1 p.m. ET, the Washington Commanders (1-3) will host the New York Giants (3-1).

• Game Preview: New York Giants at Washington Commanders
• Projected Favorite: Commanders (56.50% win probability)
• Spread: Washington (-3.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Washington vs. New York with FanDuel Sportsbook.

Patriots vs. Raiders

The Las Vegas Raiders (3-1) will visit the New England Patriots (2-2) on Sunday at 1 p.m. ET.

• Game Preview: Las Vegas Raiders at New England Patriots
• Projected Favorite: Patriots (73.51% win probability)
• Spread: New England (-3.5)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New England vs. Las Vegas with FanDuel Sportsbook.

Packers vs. Bears

Christian Watson and the Green Bay Packers (2-2) meet the Chicago Bears (3-1) on Sunday at 1 p.m. ET at Lambeau Field.

• Game Preview: Chicago Bears at Green Bay Packers
• Projected Favorite: Bears (61.29% win probability)
• Spread: Chicago (-2.5)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Green Bay vs. Chicago with FanDuel Sportsbook.

Chargers vs. Broncos

The Los Angeles Chargers (0-4) play on Sunday at 4:05 p.m. ET at SoFi Stadium versus the Denver Broncos (2-2).

• Game Preview: Denver Broncos at Los Angeles Chargers
• Projected Favorite: Broncos (53.03% win probability)
• Spread: Denver (-3.5)
• Total: 42.5 -- Over: (-106) | Under: (-114)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Los Angeles vs. Denver with FanDuel Sportsbook.

Cardinals vs. Lions

Star QB Jared Goff and the Detroit Lions (2-2) face the Arizona Cardinals (1-3) on Sunday at 4:25 p.m. ET at State Farm Stadium.

• Game Preview: Detroit Lions at Arizona Cardinals
• Projected Favorite: Lions (66.44% win probability)
• Spread: Detroit (-5.5)
• Total: 54.5 -- Over: (-108) | Under: (-112)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Arizona vs. Detroit with FanDuel Sportsbook.

Seahawks vs. 49ers

The Seattle Seahawks (3-1) host the San Francisco 49ers (4-0) on Sunday at 4:25 p.m. ET, in a battle between two of the best offensive players in football in wideout Jaxon Smith-Njigba and QB Brock Purdy.

• Game Preview: San Francisco 49ers at Seattle Seahawks
• Projected Favorite: Seahawks (57.37% win probability)
• Spread: Seattle (-3)
• Total: 45.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Seattle vs. San Francisco with FanDuel Sportsbook.

Falcons vs. Ravens

Derrick Henry, who ranks fourth-best in the league in rushing yards, will aim to lead the charge for the Baltimore Ravens (3-1) on Oct. 11 at 8:20 p.m. ET, when they visit the Atlanta Falcons (2-2) and their first-ranked run D (48.3 rushing yards allowed per game).

• Game Preview: Baltimore Ravens at Atlanta Falcons
• Projected Favorite: Ravens (52.05% win probability)
• Spread: Atlanta (-3.5)
• Total: 43.5 -- Over: (-114) | Under: (-106)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Atlanta vs. Baltimore with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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