Padres vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 6:12 a.m.

MLB action on Saturday includes the San Diego Padres playing the Chicago White Sox.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs White Sox Game Info

• San Diego Padres (83-71) vs. Chicago White Sox (58-96)
• Date: Saturday, September 20, 2025
• Time: 7:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SDPA

Padres vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-172) | CHW: (+144)
• Spread: SD: -1.5 (-100) | CHW: +1.5 (-120)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Padres vs White Sox Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 4-5, 5.63 ERA vs Yoendrys Gomez (White Sox) - 3-2, 4.91 ERA

The Padres will look to Yu Darvish (4-5) against the White Sox and Yoendrys Gomez (3-2). When Darvish starts, his team is 8-4-0 against the spread this season. Darvish's team has won 66.7% of his starts when they are favored on the moneyline (4-2). The White Sox have gone 6-1-0 ATS in Gomez's seven starts that had a set spread. The White Sox have been the moneyline underdog in seven of Gomez's starts this season, and they went 4-3 in those matchups.

Padres vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (62.3%)

Padres vs White Sox Moneyline

• Looking at the moneyline for White Sox-Padres, Chicago is the underdog at +144, and San Diego is -172 playing on the road.

Padres vs White Sox Spread

• The White Sox are +1.5 on the run line against the Padres. The White Sox are -120 to cover, and the Padres are -100.

Padres vs White Sox Over/Under

• The Padres-White Sox game on Sept. 20 has been given an over/under of 8.5 runs. The over is set at -105 and the under at -115.

Bet on San Diego Padres vs. Chicago White Sox on FanDuel today!

Padres vs White Sox Betting Trends

• The Padres have come away with 49 wins in the 83 contests they have been listed as the favorites in this season.
• San Diego has a record of 18-12 when favored by -172 or more this year.
• The Padres' games have gone over the total in 66 of their 152 opportunities.
• The Padres are 81-71-0 against the spread in their 152 games with a line set by sportsbooks this season.
• The White Sox have won 37.2% of the games this season they were the moneyline underdog (54-91).
• Chicago has a record of 24-48 in games it has played as a moneyline underdog with odds of +144 or longer (33.3%).
• The White Sox have played in 149 games with an over/under set, and have combined with their opponents to go over the total 68 times (68-73-8).
• The White Sox have an 85-64-0 record against the spread this season (covering 57% of the time).

Padres Player Leaders

• Fernando Tatis Jr. is batting .266 with 27 doubles, two triples, 22 home runs and 88 walks. He has an on-base percentage of .368 while slugging .435.
• Among qualified hitters, he is 48th in batting average, his on-base percentage ranks 13th, and he is 71st in slugging.
• Tatis has picked up at least one hit in three games in a row. During his last five outings he is hitting .421 with three walks.
• Manny Machado leads San Diego in total hits (164) this season while batting .277 with 59 extra-base hits. He's slugging .465 with an on-base percentage of .337.
• Among qualifying hitters, his batting average places him 31st, his on-base percentage 56th, and his slugging percentage 46th.
• Luis Arraez has an OPS of .706, fueled by an OBP of .321 and a team-best slugging percentage of .385 this season.
• Arraez enters this game with eight games in a row with at least one hit. During his last 10 games he is batting .324 with a walk and three RBIs.
• Ramon Laureano has been key for San Diego with 122 hits, an OBP of .346 plus a slugging percentage of .523.

White Sox Player Leaders

• Miguel Vargas has accumulated a team-best .309 on-base percentage. He's batting .228 and slugging .397.
• Including all the qualifying hitters in MLB, he ranks 134th in batting average, 112th in on-base percentage and 106th in slugging percentage.
• Andrew Benintendi is hitting .240 with 16 doubles, two triples, 20 home runs and 39 walks. He's slugging .431 with an on-base percentage of .306.
• Lenyn Sosa has a team-best slugging percentage (.424) and leads the White Sox in hits (128).
• Chase Meidroth has 15 doubles, five home runs and 44 walks while batting .267.

Padres vs White Sox Head to Head

• 9/19/2025: 4-3 CHW (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/22/2024: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -350, Underdog Moneyline: +280)
• 9/21/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/20/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 10/1/2023: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/30/2023: 6-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/29/2023: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 10/2/2022: 2-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2022: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/30/2022: 3-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)

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