Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 6:12 a.m.

On Saturday in MLB, the Milwaukee Brewers are up against the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (94-60) vs. St. Louis Cardinals (75-79)
• Date: Saturday, September 20, 2025
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSWI

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-138) | STL: (+118)
• Spread: MIL: -1.5 (+112) | STL: +1.5 (-134)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Chad Patrick (Brewers) - 3-8, 3.64 ERA vs Miles Mikolas (Cardinals) - 8-10, 4.80 ERA

This contest's pitching matchup is set, as the Brewers will send Chad Patrick (3-8) to the mound, while Miles Mikolas (8-10) will get the nod for the Cardinals. Patrick and his team are 6-13-0 ATS this season when he starts. Patrick's team has a record of 3-7 this season when he starts and they are the favorite on the moneyline. The Cardinals have a 13-16-0 record against the spread in Mikolas' starts. The Cardinals have been the moneyline underdog in 21 of Mikolas' starts this season, and they went 9-12 in those games.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (58.6%)

Brewers vs Cardinals Moneyline

• The Brewers vs Cardinals moneyline has Milwaukee as a -138 favorite, while St. Louis is a +118 underdog at home.

Brewers vs Cardinals Spread

• The Brewers are at the Cardinals and are favored by 1.5 runs (+112 to cover) on the runline. St. Louis is -134 to cover.

Brewers vs Cardinals Over/Under

• The over/under for the Brewers versus Cardinals game on Sept. 20 has been set at 8.5, with -120 odds on the over and -102 odds on the under.

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Brewers vs Cardinals Betting Trends

• The Brewers have won in 58, or 65.2%, of the 89 contests they have been named as odds-on favorites in this year.
• This year Milwaukee has won 36 of 49 games when listed as at least -138 on the moneyline.
• The Brewers' games have gone over the total in 77 of their 151 opportunities.
• The Brewers are 85-66-0 against the spread in their 151 games that had a posted line this season.
• The Cardinals have won 40 of the 83 games they were listed as the moneyline underdog this season (48.2%).
• St. Louis has a 17-26 record (winning just 39.5% of its games) when playing as a moneyline underdog of +118 or longer.
• The Cardinals have played in 148 games with a set over/under, and have combined with their opponents to go over the total 76 times (76-67-5).
• The Cardinals have gone 74-74-0 against the spread this season.

Brewers Player Leaders

• William Contreras has 27 doubles, 17 home runs and 82 walks while batting .264. He has an on-base percentage of .359 and a slugging percentage of .406.
• Among all qualified hitters in the majors, he ranks 55th in batting average, 23rd in on-base percentage, and 94th in slugging.
• Brice Turang has hit 18 homers this season while driving in 76 runs. He's batting .287 this season and slugging .438 with an on-base percentage of .357.
• Among all qualified hitters, he ranks 16th in batting average, 25th in on-base percentage and 69th in slugging percentage.
• Christian Yelich has 146 hits this season and has a slash line of .269/.346/.466.
• Yelich takes a two-game hitting streak into this game. In his last five games he is hitting .381 with two doubles, a home run, a walk and four RBIs.
• Jackson Chourio has 143 hits, which is tops among Milwaukee hitters this season, while batting .278 with 58 extra-base hits.
• Chourio has hit safely in two games in a row. In his last five games he is batting .182 with a double, a walk and an RBI.

Cardinals Player Leaders

• Alec Burleson has put up a team-high slugging percentage (.466) and paces the Cardinals in hits (136). He's batting .289 and with an on-base percentage of .342.
• He is 13th in batting average, 50th in on-base percentage and 43rd in slugging percentage among all qualified hitters in the majors.
• Burleson heads into this matchup on a four-game hitting streak. During his last five outings he is batting .471 with three doubles, a home run, two walks and three RBIs.
• Brendan Donovan's .351 OBP leads his team. He has a batting average of .283 while slugging .410.
• Including all qualifying hitters, he ranks 20th in batting average, 35th in on-base percentage and 90th in slugging percentage.
• Lars Nootbaar has 23 doubles, a triple, 13 home runs and 59 walks while hitting .237.
• Ivan Herrera is batting .280 with 13 doubles, 16 home runs and 38 walks.

Brewers vs Cardinals Head to Head

• 9/19/2025: 7-1 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2025: 6-0 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/27/2025: 7-1 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)

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