Padres vs Phillies Prediction, Odds, Moneyline, Spread & Over/Under for May 26

Odds updated as of 5:12 a.m.

The MLB slate on Tuesday includes the San Diego Padres taking on the Philadelphia Phillies.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Padres vs Phillies Game Info

• San Diego Padres (31-22) vs. Philadelphia Phillies (27-27)
• Date: Tuesday, May 26, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and NBCS-PH

Padres vs Phillies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-118) | PHI: (+100)
• Spread: SD: +1.5 (-200) | PHI: -1.5 (+164)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Padres vs Phillies Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 5-2, 2.96 ERA vs Aaron Nola (Phillies) - 2-4, 6.04 ERA

The Padres will give the nod to Randy Vasquez (5-2) versus the Phillies and Aaron Nola (2-4). Vasquez's team is 7-3-0 against the spread this season in his starts. Vasquez's team has been victorious in 80% of the games he's started as the moneyline favorite with a record of 4-1. The Phillies have gone 3-7-0 against the spread when Nola starts. The Phillies are 2-2 in Nola's four starts this season that they were the moneyline underdog.

Padres vs Phillies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (50.6%)

Padres vs Phillies Moneyline

• Philadelphia is a +100 underdog on the moneyline, while San Diego is a -118 favorite at home.

Padres vs Phillies Spread

• The Phillies are 1.5-run favorites against the spread for this matchup with the Padres. The Phillies are +164 to cover, while the Padres are -200 to cover as a 1.5-run underdog on the runline.

Padres vs Phillies Over/Under

• Padres versus Phillies on May 26 has an over/under of 7.5 runs, with the odds on the over -118 and the under set at -104.

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Padres vs Phillies Betting Trends

• The Padres have come away with 15 wins in the 26 contests they have been listed as the favorites in this season.
• San Diego has a record of 14-10 when favored by -118 or more this year.
• The Padres and their opponents have hit the over in 22 of their 53 games with a total set by oddsmakers this season.
• The Padres are 30-23-0 against the spread in their 53 games with a line set by sportsbooks this season.
• The Phillies have won 33.3% of the games this season they were the underdog on the moneyline (5-10).
• In games it has played as a moneyline underdog with odds of +100 or longer, Philadelphia has a 3-6 record (winning just 33.3% of its games).
• The Phillies have played in 53 games with a set over/under, and have combined with opponents to go over the total 24 times (24-27-2).
• The Phillies are 16-37-0 ATS this season.

Padres Player Leaders

• Xander Bogaerts leads San Diego in total hits (45) this season while batting .245 with 10 extra-base hits. He has an on-base percentage of .314 and a slugging percentage of .375.
• Among all qualified hitters in MLB, he ranks 94th in batting average, 108th in on-base percentage, and 110th in slugging.
• Gavin Sheets is hitting .253 with 10 doubles, nine home runs and 16 walks, while slugging .507 with an on-base percentage of .331.
• Sheets has picked up a hit in four games in a row. In his last five games he is batting .235 with two walks and two RBIs.
• Miguel Andujar is batting .281 with a .484 slugging percentage and 17 RBI this year.
• Andujar brings a two-game hitting streak into this game. In his last five games he is hitting .158 with a double and a walk.
• Manny Machado has been key for San Diego with 31 hits, an OBP of .265 plus a slugging percentage of .330.

Phillies Player Leaders

• Bryce Harper has a team-best .360 on-base percentage. He's batting .269 and slugging .518.
• Including all qualified hitters in the big leagues, he ranks 50th in batting average, 37th in on-base percentage and 18th in slugging percentage.
• Kyle Schwarber paces his team with 45 hits. He has a batting average of .233 while slugging .617 with an on-base percentage of .354.
• He is currently 114th in batting average, 49th in on-base percentage and first in slugging percentage among all qualifying hitters.
• Brandon Marsh has a team-high .475 slugging percentage.
• Bryson Stott is batting .236 with eight doubles, two triples, five home runs and 11 walks.

Padres vs Phillies Head to Head

• 5/25/2026: 3-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 7/13/2025: 2-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/12/2025: 5-4 SD (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 7/11/2025: 4-2 SD (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/2/2025: 5-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/2/2025: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/30/2025: 4-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 6/19/2024: 5-2 SD (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/18/2024: 4-3 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/17/2024: 9-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

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