Giants vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for May 26

Odds updated as of 5:12 a.m.

The MLB's Tuesday schedule includes the San Francisco Giants facing the Arizona Diamondbacks.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Giants vs Diamondbacks Game Info

• San Francisco Giants (22-32) vs. Arizona Diamondbacks (29-24)
• Date: Tuesday, May 26, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Dbacks.TV

Giants vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-110) | ARI: (-106)
• Spread: SF: +1.5 (-205) | ARI: -1.5 (+168)
• Total: 8 -- Over: (-105) | Under: (-115)

Giants vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Tyler Mahle (Giants) - 1-6, 6.10 ERA vs Eduardo Rodríguez (Diamondbacks) - 4-1, 2.24 ERA

The probable starters are Tyler Mahle (1-6) for the Giants and Eduardo Rodriguez (4-1) for the Diamondbacks. Mahle and his team are 3-7-0 ATS this season when he starts. Mahle's team is 1-1 this season when he starts and they're favored on the moneyline. The Diamondbacks are 7-3-0 against the spread when Rodriguez starts. The Diamondbacks have a 3-2 record in Rodríguez's five starts this season when they were the moneyline underdog.

Giants vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (51.5%)

Giants vs Diamondbacks Moneyline

• Looking at the moneyline for Giants-Diamondbacks, San Francisco is the favorite at -110, and Arizona is -106 playing on the road.

Giants vs Diamondbacks Spread

• The Diamondbacks are 1.5-run favorites against the spread for this matchup with the Giants. The Diamondbacks are +168 to cover, while the Giants are -205 to cover as a 1.5-run underdog on the runline.

Giants vs Diamondbacks Over/Under

• The over/under for the Giants versus Diamondbacks contest on May 26 has been set at 8, with -105 odds on the over and -115 odds on the under.

Bet on San Francisco Giants vs. Arizona Diamondbacks on FanDuel today!

Giants vs Diamondbacks Betting Trends

• The Giants have been chosen as favorites in 16 games this year and have walked away with the win eight times (50%) in those games.
• San Francisco has a record of 8-8 in contests when bookmakers favor them by -110 or more on the moneyline.
• The Giants and their opponents have gone over the total this season in 26 of their 54 opportunities.
• The Giants have posted a record of 22-32-0 against the spread this season.
• The Diamondbacks have compiled a 10-17 record in games they were listed as the moneyline underdog (winning 37% of those games).
• When it has played as a moneyline underdog with odds of -106 or longer, Arizona has gone 10-17 (37%).
• The Diamondbacks have combined with opponents to hit the over on the total 26 times this season for a 26-24-2 record against the over/under.
• The Diamondbacks have a 31-21-0 record ATS this season (covering 59.6% of the time).

Giants Player Leaders

• Luis Arraez has an OPS of .789, fueled by an OBP of .361 to go with a slugging percentage of .428. He has a .318 batting average, as well.
• Among qualified hitters in the majors, his batting average ranks third, his on-base percentage ranks 36th, and he is 67th in slugging.
• Casey Schmitt has 51 hits, which is tops among San Francisco batters this season. He's batting .295 with 22 extra-base hits. He's also slugging .555 with an on-base percentage of .337.
• He is 19th in batting average, 76th in on-base percentage and ninth in slugging in MLB.
• Schmitt heads into this game looking to extend his three-game hit streak. During his last five outings he is hitting .300 with two doubles, three home runs, a walk and eight RBIs.
• Rafael Devers has 51 hits this season and has a slash line of .246/.291/.415.
• Devers heads into this matchup with three games in a row with at least one hit. During his last five outings he is hitting .250 with three doubles, a home run and seven RBIs.
• Willy Adames has six home runs, 17 RBI and a batting average of .235 this season.
• Adames has safely hit in four straight games. In his last five games he is batting .190 with a double, a home run, two walks and two RBIs.

Diamondbacks Player Leaders

• Corbin Carroll has racked up 55 hits with a .399 on-base percentage and a .575 slugging percentage, all club-highs for the Diamondbacks. He's batting .304.
• Including all qualified hitters in the big leagues, his batting average places him eighth, his on-base percentage ranks eighth, and he is sixth in slugging.
• Carroll heads into this game on a 13-game hitting streak. In his last 10 outings he is hitting .429 with two doubles, four triples, two home runs, four walks and eight RBIs.
• Ketel Marte paces his team with a .470 slugging percentage. He has a batting average of .275 with an on-base percentage of .327.
• Including all qualifying hitters, he ranks 44th in batting average, 85th in on-base percentage and 40th in slugging percentage.
• Ildemaro Vargas has a team-high .486 slugging percentage.
• Nolan Arenado is hitting .268 with 11 doubles, seven home runs and 17 walks.

Giants vs Diamondbacks Head to Head

• 5/25/2026: 6-2 ARI (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/20/2026: 6-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 5/19/2026: 5-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/18/2026: 12-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/17/2025: 5-1 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/16/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/15/2025: 8-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 5-3 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/9/2025: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2025: 11-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!