Padres vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 11

Odds updated as of 5:13 a.m.

The San Diego Padres will take on the San Francisco Giants in MLB action on Friday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Padres vs Giants Game Info

• San Diego Padres (78-68) vs. San Francisco Giants (62-85)
• Date: Friday, September 11, 2026
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: Apple TV+

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-146) | SF: (+124)
• Spread: SD: -1.5 (+115) | SF: +1.5 (-138)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Padres) - 11-8, 3.39 ERA vs Anthony Molina (Giants) - 3-0, 2.79 ERA

The Padres will look to Robbie Ray (11-8) against the Giants and Anthony Molina (3-0). When Ray starts, his team is 15-10-0 against the spread this season. Ray's team has been victorious in 58.3% of the games he's started as the moneyline favorite with a record of 7-5. Molina has started two games with set spreads, and the Giants covered in both opportunities. The Giants were the underdog on the moneyline for two Molina starts this season -- they won both.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (51%)

Padres vs Giants Moneyline

• The moneyline numbers for Padres vs. Giants reveal San Diego as the favorite (-146) and San Francisco as the underdog (+124) despite being the home team.

Padres vs Giants Spread

• The Giants are hosting the Padres, and are +1.5 on the runline. The Giants are +115 to cover the spread, and the Padres are -138.

Padres vs Giants Over/Under

• The over/under for Padres-Giants on Sept. 11 is 7.5. The over is -122, and the under is +100.

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Padres vs Giants Betting Trends

• The Padres have been favorites in 68 games this season and have come away with the win 39 times (57.4%) in those contests.
• This year San Diego has won 16 of 24 games when listed as at least -146 on the moneyline.
• The Padres' games have gone over the total in 64 of their 146 opportunities.
• The Padres are 84-62-0 against the spread in their 146 games that had a posted line this season.
• The Giants have been the moneyline underdog 98 total times this season. They've finished 37-61 in those games.
• When it has played as a moneyline underdog with odds of +124 or longer, San Francisco has a 17-25 record (winning 40.5% of its games).
• The Giants have had an over/under set by bookmakers 144 times, and have combined with opponents to go over the total in 69 of those games (69-65-10).
• The Giants have put together a 69-75-0 record against the spread this season (covering 47.9% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 161 hits and an OBP of .351, plus a team-best slugging percentage of .449. He's batting .284.
• Among qualified hitters in MLB, his batting average ranks 16th, his on-base percentage ranks 38th, and he is 47th in slugging.
• Manny Machado is hitting .224 with 22 doubles, 26 home runs and 71 walks, while slugging .414 with an on-base percentage of .314.
• Among qualifying hitters, his batting average ranks him 120th, his on-base percentage 95th, and his slugging percentage 77th.
• Jackson Merrill has 135 hits this season and has a slash line of .245/.295/.431.
• Ty France has been key for San Diego with 114 hits, an OBP of .363 plus a slugging percentage of .510.
• France takes a two-game hitting streak into this game. During his last five outings he is hitting .278 with a double, two walks and an RBI.

Giants Player Leaders

• Rafael Devers has racked up an on-base percentage of .340, a slugging percentage of .518, and has 142 hits, all club-highs for the Giants (while batting .258).
• Including all qualifying players, he is 64th in batting average, while his on-base percentage is 54th and he is ninth in slugging.
• Jung Hoo Lee's .408 slugging percentage paces his team. He has a batting average of .281 with an on-base percentage of .324.
• Including all qualified hitters, he is 23rd in batting average, 78th in on-base percentage and 84th in slugging percentage.
• Bryce Eldridge has 21 doubles, 16 home runs and 55 walks while batting .268.
• Drew Gilbert is batting .232 with 14 doubles, three triples, eight home runs and 34 walks.

Padres vs Giants Head to Head

• 8/2/2026: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +110)
• 8/1/2026: 6-5 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +134)
• 7/31/2026: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 7/30/2026: 4-1 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/6/2026: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: -106)
• 5/5/2026: 10-5 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/4/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -194, Underdog Moneyline: +150)
• 4/1/2026: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)

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