Cubs vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 11

Odds updated as of 4:12 a.m.

MLB action on Friday includes the Chicago Cubs taking on the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Cubs vs Pirates Game Info

• Chicago Cubs (81-66) vs. Pittsburgh Pirates (74-73)
• Date: Friday, September 11, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and SportsNet PT

Cubs vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-184) | PIT: (+154)
• Spread: CHC: -1.5 (+122) | PIT: +1.5 (-146)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Cubs vs Pirates Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 9-10, 3.91 ERA vs Wilber Dotel (Pirates) - 1-4, 4.41 ERA

The probable pitchers are Shota Imanaga (9-10) for the Cubs and Wilber Dotel (1-4) for the Pirates. Imanaga's team is 12-15-0 against the spread this season in his starts. Imanaga's team is 13-11 this season when he starts and they are the moneyline favorite. Dotel and his team were moneyline underdogs each time he pitched a season ago.

Cubs vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (52%)

Cubs vs Pirates Moneyline

• The moneyline numbers for Cubs vs. Pirates reveal Chicago as the favorite (-184) and Pittsburgh as the underdog (+154) on the road.

Cubs vs Pirates Spread

• The Pirates are at +1.5 on the runline against the Cubs. The Pirates are -146 to cover the spread, and the Cubs are +122.

Cubs vs Pirates Over/Under

• A combined run total of 8.5 has been set for Cubs-Pirates on Sept. 11, with the over at -105 and the under at -115.

Bet on Chicago Cubs vs. Pittsburgh Pirates on FanDuel today!

Cubs vs Pirates Betting Trends

• The Cubs have been victorious in 53, or 56.4%, of the 94 contests they have been chosen as favorites in this season.
• This season Chicago has come away with a win eight times in 12 chances when named as a favorite of at least -184 on the moneyline.
• Contests with the Cubs have gone over the total set by bookmakers in 79 of 142 chances this season.
• In 142 games with a line this season, the Cubs have a mark of 68-74-0 against the spread.
• The Pirates have won 44.8% of the games this season they were the underdog on the moneyline (30-37).
• Pittsburgh is 3-4 (winning 42.9% of its games) when it has played as a moneyline underdog of +154 or longer.
• The Pirates have played in 145 games with an over/under set, and have combined with their opponents to go over the total 75 times (75-66-4).
• The Pirates have covered 48.3% of their games this season, going 70-75-0 against the spread.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago with 159 hits and an OBP of .375, plus a team-best slugging percentage of .572. He's batting .281.
• Among qualified hitters in baseball, his batting average ranks 23rd, his on-base percentage ranks ninth, and he is second in slugging.
• Crow-Armstrong will look for his ninth straight game with a hit in this contest. In his last 10 games he is batting .256 with a double, three home runs, five walks and six RBIs.
• Alex Bregman is batting .260 with 29 doubles, a triple, 24 home runs and 71 walks. He's slugging .440 with an on-base percentage of .349.
• His batting average is 58th among qualified players, his on-base percentage 44th, and his slugging percentage 55th.
• Seiya Suzuki has collected 131 base hits, an OBP of .366 and a slugging percentage of .475 this season.
• Nico Hoerner has been key for Chicago with 152 hits, an OBP of .318 plus a slugging percentage of .358.
• Hoerner takes a two-game hitting streak into this game. In his last five games he is hitting .333 with two RBIs.

Pirates Player Leaders

• Bryan Reynolds a has .369 on-base percentage to pace the Pirates. He's batting .264 while slugging .426.
• Including all the qualified hitters in the big leagues, he ranks 55th in batting average, 17th in on-base percentage and 65th in slugging percentage.
• Brandon Lowe paces his team with 138 hits. He has a batting average of .257 while slugging .476 with an on-base percentage of .326.
• Including all qualifying players, he ranks 66th in batting average, 71st in on-base percentage and 26th in slugging percentage.
• Nick Gonzales has racked up a team-high .393 slugging percentage.
• Oneil Cruz is batting .276 with 12 doubles, a triple, 18 home runs and 41 walks.

Cubs vs Pirates Head to Head

• 7/26/2026: 8-7 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/25/2026: 11-0 CHC (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 3-2 CHC (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/28/2026: 7-2 CHC (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/27/2026: 10-4 CHC (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/26/2026: 12-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/25/2026: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/12/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 12.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/11/2026: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/10/2026: 2-0 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!