White Sox vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 11

Odds updated as of 4:12 a.m.

Friday's slate in the MLB includes a matchup between the Chicago White Sox and the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

White Sox vs Cardinals Game Info

• Chicago White Sox (75-71) vs. St. Louis Cardinals (72-75)
• Date: Friday, September 11, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CHSN

White Sox vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-110) | STL: (-106)
• Spread: CHW: -1.5 (+155) | STL: +1.5 (-188)
• Total: 8.5 -- Over: (-104) | Under: (-118)

White Sox vs Cardinals Probable Starting Pitchers

Probable Pitchers: Anthony Kay (White Sox) - 9-8, 4.53 ERA vs Matthew Liberatore (Cardinals) - 5-14, 5.57 ERA

This contest's pitching matchup is set, as the White Sox will send Anthony Kay (9-8) to the mound, while Matthew Liberatore (5-14) will answer the bell for the Cardinals. When Kay starts, his team is 18-8-0 against the spread this season. Kay's team is 1-3 this season when he starts and they are the moneyline favorite. The Cardinals are 13-14-0 against the spread when Liberatore starts. The Cardinals are 8-10 in Liberatore's 18 starts this season that they were the moneyline underdog.

White Sox vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (53.9%)

White Sox vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-White Sox, St. Louis is the underdog at -106, and Chicago is -110 playing on the road.

White Sox vs Cardinals Spread

• The White Sox are 1.5-run road favorites on the runline against the Cardinals. The White Sox are +155 to cover, and the Cardinals are -188.

White Sox vs Cardinals Over/Under

• A total of 8.5 runs has been set for the White Sox-Cardinals contest on Sept. 11, with the over available at -104 and the under at -118.

Bet on Chicago White Sox vs. St. Louis Cardinals on FanDuel today!

White Sox vs Cardinals Betting Trends

• The White Sox have won in 19, or 54.3%, of the 35 contests they have been named as odds-on favorites in this year.
• This year Chicago has won 19 of 35 games when listed as at least -110 on the moneyline.
• The White Sox and their opponents have gone over in 78 of their 143 games with a total set by sportsbooks this season.
• The White Sox are 81-62-0 against the spread in their 143 games with a line set by sportsbooks this season.
• The Cardinals have won 46.3% of the games this season they were the underdog on the moneyline (44-51).
• In games it has played as a moneyline underdog with odds of -106 or longer, St. Louis has a 44-50 record (winning 46.8% of its games).
• The Cardinals have combined with opponents to hit the over on the total 65 times this season for a 65-71-7 record against the over/under.
• The Cardinals have a 77-66-0 record against the spread this season (covering 53.8% of the time).

White Sox Player Leaders

• Miguel Vargas leads Chicago in total hits (132) this season while batting .248 with 61 extra-base hits. He has an on-base percentage of .359 and a slugging percentage of .477.
• Among all qualifying hitters, he ranks 81st in batting average, his on-base percentage ranks 33rd, and he is 25th in slugging.
• Sam Antonacci leads Chicago with an OBP of .363 this season while batting .265 with 42 walks and 72 runs scored. He's slugging .387.
• Among qualified hitters, his batting average places him 52nd, his on-base percentage 24th, and his slugging percentage 104th.
• Chase Meidroth has an OPS of .733, fueled by an OBP of .343 and a team-best slugging percentage of .390 this season.
• Tristan Peters is batting .281 with a .345 OBP and 53 RBI for Chicago this season.

Cardinals Player Leaders

• Alec Burleson has a .467 slugging percentage, which leads the Cardinals. He's batting .283 with an on-base percentage of .350.
• Including all the qualified hitters in MLB, his batting average ranks 17th, his on-base percentage ranks 40th, and he is 34th in slugging.
• Jordan Walker has collected 157 hits while slugging .489. Both pace his team. He has a batting average of .281 with an on-base percentage of .337.
• He ranks 23rd in batting average, 56th in on-base percentage and 21st in slugging percentage in MLB.
• Ivan Herrera has accumulated an on-base percentage of .361, a team-best for the Cardinals.
• Nathan Church is hitting .244 with 12 doubles, two triples, 10 home runs and 22 walks.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!