Padres vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 4

Odds updated as of 6:13 a.m.

The Monday slate in MLB includes a matchup between the San Diego Padres and the San Francisco Giants.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Giants Game Info

• San Diego Padres (20-13) vs. San Francisco Giants (13-21)
• Date: Monday, May 4, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Padres.TV

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-142) | SF: (+120)
• Spread: SD: -1.5 (+118) | SF: +1.5 (-142)
• Total: 8 -- Over: (-110) | Under: (-110)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 3-0, 2.94 ERA vs Trevor McDonald (Giants) - 0-0, 0.00 ERA

This contest's pitching matchup is set, as the Padres will send Randy Vasquez (3-0) to the mound, while Trevor McDonald will get the nod for the Giants. Vasquez and his team have a record of 5-1-0 against the spread when he starts. Vasquez has started three games with his team as the moneyline favorite and won each of them. McDonald did not pitch as a moneyline underdog a season ago.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (54.7%)

Padres vs Giants Moneyline

• San Francisco is the underdog, +120 on the moneyline, while San Diego is a -142 favorite despite being on the road.

Padres vs Giants Spread

• The Padres are 1.5-run road favorites on the runline against the Giants. The Padres are +118 to cover, and the Giants are -142.

Padres vs Giants Over/Under

• An over/under of 8 has been set for Padres-Giants on May 4, with the over being -110 and the under -110.

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Padres vs Giants Betting Trends

• The Padres have been chosen as favorites in 18 games this year and have walked away with the win 11 times (61.1%) in those games.
• San Diego has a record of 9-3 when favored by -142 or more this year.
• The Padres' games have gone over the total in 15 of their 33 opportunities.
• In 33 games with a line this season, the Padres have a mark of 19-14-0 against the spread.
• The Giants have been the moneyline underdog 23 total times this season. They've gone 8-15 in those games.
• San Francisco is 3-4 (winning 42.9% of its games) when it has played as a moneyline underdog of +120 or longer.
• The Giants have had an over/under set by oddsmakers 34 times, and have combined with opponents to go over the total in 14 of those games (14-17-3).
• The Giants have a 14-20-0 record ATS this season (covering 41.2% of the time).

Padres Player Leaders

• Xander Bogaerts has 32 hits and an OBP of .351 to go with a slugging percentage of .412. All three of those stats rank first among San Diego hitters this season. He has a .269 batting average, as well.
• Among all qualifying hitters in baseball, he ranks 54th in batting average, 65th in on-base percentage, and 84th in slugging.
• Manny Machado is batting .229 with four doubles, five home runs and 19 walks. He's slugging .404 with an on-base percentage of .338.
• His batting average is 121st among qualified players, his on-base percentage 78th, and his slugging percentage 94th.
• Jackson Merrill has 26 hits this season and has a slash line of .211/.276/.333.
• Merrill enters this game with two games in a row with at least one hit. In his last five games he is batting .200 with a walk and an RBI.
• Ramon Laureano has four home runs, 18 RBI and a batting average of .237 this season.

Giants Player Leaders

• Luis Arraez has a .377 slugging percentage, which leads the Giants. He's batting .308 with an on-base percentage of .333.
• Including all the qualifying hitters in the big leagues, his batting average ranks 21st, his on-base percentage ranks 86th, and he is 112th in slugging.
• Jung Hoo Lee is batting .281 with eight doubles, a triple, two home runs and 10 walks. He's slugging .413 with an on-base percentage of .331.
• Including all qualifying hitters, his batting average places him 40th, his on-base percentage ranks 92nd, and he is 83rd in slugging.
• Casey Schmitt has racked up a team-high OBP (.354), and leads the Giants in hits (32).
• Matt Chapman has six doubles, a triple, a home run and 14 walks while hitting .246.

Padres vs Giants Head to Head

• 4/1/2026: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 8/21/2025: 8-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2025: 4-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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