Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 4:11 a.m.

Saturday's slate in the MLB includes a matchup between the San Diego Padres and the Arizona Diamondbacks.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Diamondbacks Game Info

• San Diego Padres (89-71) vs. Arizona Diamondbacks (86-74)
• Date: Saturday, September 26, 2026
• Time: 8:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Dbacks.TV

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-116) | ARI: (-102)
• Spread: SD: +1.5 (-196) | ARI: -1.5 (+162)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 9-6, 4.56 ERA vs TBA (Diamondbacks)

The Padres will look to Walker Buehler (9-6), while the Diamondbacks' starting pitcher has not yet been announced. Buehler's team is 23-8-0 against the spread this season in his starts. Buehler's team has won 69.2% of his starts when they are favored on the moneyline (9-4).

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (60.6%)

Padres vs Diamondbacks Moneyline

• San Diego is the favorite, -116 on the moneyline, while Arizona is a -102 underdog on the road.

Padres vs Diamondbacks Spread

• The Diamondbacks are 1.5-run favorites against the spread for this matchup with the Padres. The Diamondbacks are +162 to cover, while the Padres are -196 to cover as a 1.5-run underdog on the runline.

Padres vs Diamondbacks Over/Under

• A combined run total of 7.5 has been set for Padres-Diamondbacks on Sept. 26, with the over at -110 and the under at -110.

Bet on San Diego Padres vs. Arizona Diamondbacks on FanDuel today!

Padres vs Diamondbacks Betting Trends

• The Padres have come away with 48 wins in the 79 contests they have been listed as the favorites in this season.
• San Diego has a record of 44-26 in contests when sportsbooks favor them by -116 or more on the moneyline.
• The Padres and their opponents have gone over the total this season in 75 of their 160 opportunities.
• In 160 games with a line this season, the Padres have a mark of 92-68-0 against the spread.
• The Diamondbacks have won 48.2% of the games this season they were the underdog on the moneyline (40-43).
• When it has played as a moneyline underdog with odds of -102 or longer, Arizona has a record of 32-38 (45.7%).
• In the 158 games bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 69 times (69-85-4).
• The Diamondbacks have an 84-74-0 record ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 181 hits and an OBP of .360, plus a team-best slugging percentage of .473. He's batting .291.
• He is ninth in batting average, 30th in on-base percentage, and 31st in slugging among qualifying batters in the majors.
• Tatis hopes to build on an eight-game hitting streak in this matchup. During his last 10 outings he is batting .325 with three doubles, three home runs, three walks and five RBIs.
• Jackson Merrill is hitting .253 with 26 doubles, five triples, 26 home runs and 40 walks, while slugging .440 with an on-base percentage of .301.
• Among qualified hitters, he ranks 72nd in batting average, 116th in on-base percentage and 54th in slugging percentage.
• Merrill brings a two-game streak with at least one hit into this one. In his last five games he is hitting .167 with a double.
• Manny Machado has 125 hits this season and has a slash line of .215/.302/.402.
• Xander Bogaerts has been key for San Diego with 119 hits, an OBP of .329 plus a slugging percentage of .338.

Diamondbacks Player Leaders

• Corbin Carroll has 32 doubles, 17 triples, 22 home runs and 73 walks while hitting .239. He's slugging .469 with an on-base percentage of .329.
• Including all qualifying hitters in the big leagues, he ranks 98th in batting average, 70th in on-base percentage and 34th in slugging percentage.
• Geraldo Perdomo's .379 slugging percentage leads his team. He has a batting average of .263 with an on-base percentage of .369.
• He ranks 54th in batting average, 15th in on-base percentage and 109th in slugging percentage in MLB.
• Gabriel Moreno has totaled 146 hits with a .387 on-base percentage and a .487 slugging percentage, all club-bests for the Diamondbacks.
• Ketel Marte has 30 doubles, three triples, 22 home runs and 51 walks while batting .248.

Padres vs Diamondbacks Head to Head

• 9/25/2026: 11-4 ARI (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/6/2026: 5-1 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -104, Underdog Moneyline: -104)
• 8/5/2026: 10-4 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +122)
• 8/4/2026: 9-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -114, Underdog Moneyline: +104)
• 8/3/2026: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: +100)
• 7/9/2026: 3-1 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2026: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2026: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/6/2026: 8-0 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/26/2026: 12-7 ARI (Favorite: Padres, Spread: -1.5, Total: 15, Favorite Moneyline: -134, Underdog Moneyline: +114)

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