Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 4:11 a.m.

In MLB action on Saturday, the Houston Astros play the Athletics.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Athletics Game Info

• Houston Astros (79-81) vs. Athletics (64-96)
• Date: Saturday, September 26, 2026
• Time: 9:40 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-146) | OAK: (+124)
• Spread: HOU: -1.5 (+114) | OAK: +1.5 (-137)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hayden Wesneski (Astros) - 5-2, 3.50 ERA vs Jack Perkins (Athletics) - 3-12, 5.90 ERA

The probable starters are Hayden Wesneski (5-2) for the Astros and Jack Perkins (3-12) for the Athletics. Wesneski and his team have a record of 7-3-0 against the spread when he starts. Wesneski's team has been victorious in 71.4% of the games he's started as the moneyline favorite with a record of 5-2. The Athletics are 4-11-0 against the spread when Perkins starts. The Athletics have a 1-9 record in Perkins' 10 starts this season when they were the underdog on the moneyline.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (55.9%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -146 favorite, while the Athletics are a +124 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +114 to cover, while the Athletics are -137 to cover.

Astros vs Athletics Over/Under

• A total of 8.5 runs has been set for the Astros-Athletics game on Sept. 26, with the over available at -105 and the under at -115.

Bet on Houston Astros vs. Athletics on FanDuel today!

Astros vs Athletics Betting Trends

• The Astros have been chosen as favorites in 70 games this year and have walked away with the win 36 times (51.4%) in those games.
• This year, the Astros have won nine of 25 games when listed as at least -146 or better on the moneyline.
• The Astros and their opponents have hit the over in 79 of their 160 games with a total this season.
• The Astros have an against the spread record of 80-80-0 in 160 games with a line this season.
• The Athletics have won 38.8% of the games this season they were the moneyline underdog (47-74).
• When they have played as a moneyline underdog with odds of +124 or longer, the Athletics have a record of 22-43 (33.8%).
• The Athletics have played in 159 games with a set over/under, and have combined with their opponents to go over the total 84 times (84-73-2).
• The Athletics have collected a 76-83-0 record ATS this season.

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.433), slugging percentage (.599) and total hits (176) this season. He has a .315 batting average.
• Among qualified batters in the majors, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Alvarez has hit safely in 10 games in a row. In his last 10 games he is hitting .400 with three doubles, three home runs, eight walks and six RBIs.
• Isaac Paredes is batting .260 with 27 doubles, a triple, 24 home runs and 70 walks, while slugging .442 with an on-base percentage of .358.
• Among all qualified hitters, he ranks 61st in batting average, 33rd in on-base percentage and 51st in slugging percentage.
• Christian Walker has collected 126 base hits, an OBP of .296 and a slugging percentage of .420 this season.
• Walker has recorded at least one base hit in four games in a row. In his last five games he is hitting .263 with three home runs, two walks and five RBIs.
• Jose Altuve is batting .249 with a .304 OBP and 47 RBI for Houston this season.

Athletics Player Leaders

• Jeff McNeil has a .373 slugging percentage, which paces the Athletics. He's batting .267 with an on-base percentage of .315.
• Including all qualified hitters in MLB, his batting average puts him 46th, his on-base percentage is 97th, and he is 115th in slugging.
• McNeil enters this game on a three-game hitting streak. In his last five games he is batting .333 with a double, a home run, two walks and five RBIs.
• Zack Gelof is hitting .256 with 16 doubles, two triples, 22 home runs and 31 walks. He's slugging .479 with an on-base percentage of .323.
• Shea Langeliers has 21 doubles, 23 home runs and 36 walks while batting .263.
• Lawrence Butler paces his team with 110 hits and a .326 OBP.

Astros vs Athletics Head to Head

• 9/25/2026: 6-5 OAK (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 9/24/2026: 7-5 HOU (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/23/2026: 7-6 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 8/22/2026: 4-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +215)
• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

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