Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 5:11 a.m.

The San Diego Padres versus the Arizona Diamondbacks is on the MLB schedule for Friday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Padres vs Diamondbacks Game Info

• San Diego Padres (89-70) vs. Arizona Diamondbacks (85-74)
• Date: Friday, September 25, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Dbacks.TV

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-132) | ARI: (+112)
• Spread: SD: -1.5 (+172) | ARI: +1.5 (-210)
• Total: 7.5 -- Over: (-108) | Under: (-112)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Casey Mize (Padres) - 6-9, 3.96 ERA vs Brandon Pfaadt (Diamondbacks) - 7-3, 3.72 ERA

This contest's pitching matchup is set, as the Padres will send Casey Mize (6-9) to the mound, while Brandon Pfaadt (7-3) will take the ball for the Diamondbacks. Mize's team is 11-14-0 against the spread this season in his starts. Mize's team is 9-6 this season when he starts and they are the moneyline favorite. The Diamondbacks have a 15-3-0 ATS record in Pfaadt's 18 starts with a set spread. The Diamondbacks have an 8-3 record in Pfaadt's 11 starts this season when they were the underdog on the moneyline.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (64.1%)

Padres vs Diamondbacks Moneyline

• Looking at the moneyline for Diamondbacks-Padres, Arizona is the underdog at +112, and San Diego is -132 playing at home.

Padres vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the run line against the Padres. The Diamondbacks are -210 to cover, and the Padres are +172.

Padres vs Diamondbacks Over/Under

• The over/under for the Padres versus Diamondbacks contest on Sept. 25 has been set at 7.5, with -108 odds on the over and -112 odds on the under.

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Padres vs Diamondbacks Betting Trends

• The Padres have been victorious in 48, or 61.5%, of the 78 contests they have been chosen as favorites in this season.
• San Diego has a record of 34-15 when favored by -132 or more this year.
• The Padres and their opponents have gone over in 74 of their 159 games with a total set by sportsbooks this season.
• In 159 games with a line this season, the Padres have a mark of 92-67-0 against the spread.
• The Diamondbacks have won 39 of the 82 games they were listed as the moneyline underdog this season (47.6%).
• Arizona has a 24-26 record (winning 48% of its games) when playing as a moneyline underdog of +112 or longer.
• The Diamondbacks have had an over/under set by bookmakers 157 times, and have combined with opponents to go over the total in 68 of those games (68-85-4).
• The Diamondbacks are 83-74-0 ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in OBP (.358), slugging percentage (.470) and total hits (179) this season. He has a .289 batting average.
• Among qualified hitters in MLB, his batting average ranks 12th, his on-base percentage ranks 33rd, and he is 31st in slugging.
• Tatis has hit safely in seven straight games. During his last 10 games he is hitting .286 with two doubles, four home runs, three walks and seven RBIs.
• Jackson Merrill is batting .252 with 26 doubles, five triples, 26 home runs and 40 walks. He's slugging .440 with an on-base percentage of .300.
• Among qualifying batters, he ranks 75th in batting average, 115th in on-base percentage and 54th in slugging percentage.
• Manny Machado has 125 hits this season and has a slash line of .216/.304/.405.
• Xander Bogaerts has been key for San Diego with 117 hits, an OBP of .327 plus a slugging percentage of .335.

Diamondbacks Player Leaders

• Corbin Carroll is hitting .240 with 32 doubles, 17 triples, 22 home runs and 73 walks. He's slugging .472 with an on-base percentage of .331.
• Including all qualified hitters, he ranks 96th in batting average, while his on-base percentage ranks 67th and he is 30th in slugging.
• Carroll brings a four-game hitting streak into this game. During his last five outings he is batting .250 with a double, a triple, three walks and six RBIs.
• Gabriel Moreno has 144 hits with a .384 on-base percentage while slugging .486. Those stats are all team-highs. He also has a batting average of .308.
• He is third in batting average, seventh in on-base percentage and 20th in slugging percentage in the majors.
• Geraldo Perdomo has a slugging percentage of .373, a team-high for the Diamondbacks.
• Ketel Marte is batting .250 with 30 doubles, three triples, 22 home runs and 50 walks.

Padres vs Diamondbacks Head to Head

• 8/6/2026: 5-1 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -104, Underdog Moneyline: -104)
• 8/5/2026: 10-4 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +122)
• 8/4/2026: 9-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -114, Underdog Moneyline: +104)
• 8/3/2026: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: +100)
• 7/9/2026: 3-1 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2026: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2026: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/6/2026: 8-0 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/26/2026: 12-7 ARI (Favorite: Padres, Spread: -1.5, Total: 15, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/25/2026: 6-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 16, Favorite Moneyline: -116, Underdog Moneyline: -102)

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