Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 5:11 a.m.

On Friday in MLB, the Houston Astros are up against the Athletics.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Astros vs Athletics Game Info

• Houston Astros (79-80) vs. Athletics (63-96)
• Date: Friday, September 25, 2026
• Time: 9:40 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-172) | OAK: (+144)
• Spread: HOU: -1.5 (+100) | OAK: +1.5 (-120)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 6-3, 3.26 ERA vs Jacob Lopez (Athletics) - 6-5, 5.68 ERA

The Astros will give the nod to Hunter Brown (6-3, 3.26 ERA), who is eyeing win No. 7 on the season, and the Athletics will turn to Jacob Lopez (6-5, 5.68 ERA). Brown's team is 9-10-0 against the spread this season in his starts. Brown's team has a record of 8-8 this season when he starts and they are the favorite on the moneyline. The Athletics have a 13-10-0 ATS record in Lopez's 23 starts that had a set spread. The Athletics have an 11-10 record in Lopez's 21 starts this season when they were the underdog on the moneyline.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (50.1%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -172 favorite, while the Athletics are a +144 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +100 to cover, while the Athletics are -120 to cover.

Astros vs Athletics Over/Under

• The Astros-Athletics game on Sept. 25 has been given an over/under of 8.5 runs. The over is set at -110 and the under at -110.

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Astros vs Athletics Betting Trends

• The Astros have won in 36, or 52.2%, of the 69 contests they have been named as odds-on favorites in this year.
• This year, the Astros have won four of 13 games when listed as at least -172 or better on the moneyline.
• The Astros and their opponents have hit the over in 78 of their 159 games with a total this season.
• The Astros are 80-79-0 against the spread in their 159 games that had a posted line this season.
• The Athletics have been the underdog on the moneyline 120 total times this season. They've gone 46-74 in those games.
• The Athletics have a record of 11-30 when playing as a moneyline underdog with odds of +144 or longer (26.8%).
• The Athletics have played in 158 games with an over/under set, and have combined with their opponents to go over the total 83 times (83-73-2).
• The Athletics have covered 47.5% of their games this season, going 75-83-0 against the spread.

Astros Player Leaders

• Yordan Alvarez has 175 hits and an OBP of .432 to go with a slugging percentage of .600. All three of those stats rank first among Houston hitters this season. He has a .315 batting average, as well.
• Among all qualified hitters in the majors, he ranks first in batting average, first in on-base percentage, and first in slugging.
• Alvarez has recorded at least one hit in nine games in a row. In his last 10 outings he is batting .394 with three doubles, three home runs, eight walks and six RBIs.
• Isaac Paredes is hitting .261 with 27 doubles, a triple, 24 home runs and 69 walks. He's slugging .445 with an on-base percentage of .359.
• He ranks 60th in batting average, 31st in on-base percentage and 50th in slugging among qualified batters.
• Paredes takes a three-game streak with at least one hit into this one. In his last five games he is batting .333 with a double, three home runs, four walks and five RBIs.
• Christian Walker is batting .223 with a .415 slugging percentage and 84 RBI this year.
• Walker has picked up a hit in three games in a row. In his last five games he is batting .300 with two home runs, a walk and four RBIs.
• Jeremy Pena has 20 home runs, 51 RBI and a batting average of .274 this season.
• Pena brings a four-game hitting streak into this game. In his last five games he is hitting .182 with a triple.

Athletics Player Leaders

• Jeff McNeil has a .374 slugging percentage, which paces the Athletics. He's batting .267 with an on-base percentage of .316.
• Including all the qualified hitters in the majors, his batting average ranks 45th, his on-base percentage is 96th, and he is 112th in slugging.
• Zack Gelof is hitting .259 with 16 doubles, two triples, 22 home runs and 31 walks. He's slugging .484 with an on-base percentage of .326.
• Shea Langeliers is hitting .265 with 21 doubles, 23 home runs and 35 walks.
• Lawrence Butler paces his team with 110 hits and a .328 on-base percentage.

Astros vs Athletics Head to Head

• 9/24/2026: 7-5 HOU (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/23/2026: 7-6 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 8/22/2026: 4-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +215)
• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/3/2026: 11-4 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -108, Underdog Moneyline: -108)

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