Mariners vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 5:11 a.m.

The MLB schedule on Friday includes the Seattle Mariners taking on the Los Angeles Angels.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Angels Game Info

• Seattle Mariners (74-85) vs. Los Angeles Angels (61-98)
• Date: Friday, September 25, 2026
• Time: 10:10 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: Mariners.TV and ABTV

Mariners vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-132) | LAA: (+112)
• Spread: SEA: -1.5 (+180) | LAA: +1.5 (-220)
• Total: 6.5 -- Over: (-138) | Under: (+112)

Mariners vs Angels Probable Starting Pitchers

Probable Pitchers: Bryce Miller (Mariners) - 4-9, 3.99 ERA vs Reid Detmers (Angels) - 6-8, 3.47 ERA

The probable pitchers are Bryce Miller (4-9) for the Mariners and Reid Detmers (6-8) for the Angels. When Miller starts, his team is 2-17-0 against the spread this season. Miller's team has a record of 3-12 this season when he starts and they are the favorite on the moneyline. The Angels have a 15-16-0 record against the spread in Detmers' starts. The Angels are 7-16 in Detmers' 23 starts this season that they were the moneyline underdog.

Mariners vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (50.7%)

Mariners vs Angels Moneyline

• Seattle is the favorite, -132 on the moneyline, while Los Angeles is a +112 underdog on the road.

Mariners vs Angels Spread

• The Angels are at the Mariners, and are +1.5 on the runline. The Angels are +180 to cover the spread, and the Mariners are -220.

Mariners vs Angels Over/Under

• The over/under for the Mariners versus Angels game on Sept. 25 has been set at 6.5, with -138 odds on the over and +112 odds on the under.

Bet on Seattle Mariners vs. Los Angeles Angels on FanDuel today!

Mariners vs Angels Betting Trends

• The Mariners have come away with 60 wins in the 122 contests they have been listed as the favorites in this season.
• This season Seattle has come away with a win 45 times in 81 chances when named as a favorite of at least -132 on the moneyline.
• The Mariners and their opponents have gone over the total this season in 83 of their 157 opportunities.
• In 157 games with a line this season, the Mariners have a mark of 56-101-0 against the spread.
• The Angels have compiled a 45-82 record in games they were listed as the moneyline underdog (winning 35.4% of those games).
• Los Angeles has a record of 35-59 in games it has played as a moneyline underdog with odds of +112 or longer (37.2%).
• The Angels have had an over/under set by oddsmakers 158 times, and have combined with opponents to go over the total in 67 of those games (67-88-3).
• The Angels have gone 83-75-0 ATS this season.

Mariners Player Leaders

• Randy Arozarena leads Seattle in OBP (.380), slugging percentage (.479) and total hits (156) this season. He has a .279 batting average.
• Among qualified batters in baseball, he is 25th in batting average, 10th in on-base percentage, and 25th in slugging.
• Arozarena will look for his third straight game with a hit in this contest. During his last five outings he is batting .200 with a double, a home run, five walks and an RBI.
• Josh Naylor is hitting .265 with 22 doubles, 10 home runs and 44 walks. He's slugging .354 with an on-base percentage of .321.
• He ranks 49th in batting average, 85th in on-base percentage and 126th in slugging among qualifying hitters.
• Julio Rodriguez has 147 hits this season and has a slash line of .250/.311/.407.
• Rodriguez takes a five-game hitting streak into this game. In his last five games he is hitting .526 with two doubles, a home run, a walk and four RBIs.
• Dominic Canzone has been key for Seattle with 121 hits, an OBP of .330 plus a slugging percentage of .477.

Angels Player Leaders

• Zach Neto has totaled 145 hits with a .431 slugging percentage, both team-best marks for the Angels. He's batting .238 and with an on-base percentage of .327.
• He is 101st in batting average, 77th in on-base percentage and 63rd in slugging percentage among all qualifying hitters in the big leagues.
• Neto enters this matchup on a three-game hitting streak. During his last five outings he is batting .176 with five walks and an RBI.
• Mike Trout's .385 OBP leads his team. He has a batting average of .246 while slugging .428.
• Including all qualifying hitters, his batting average puts him 87th, his on-base percentage is fifth, and he is 65th in slugging.
• Vaughn Grissom is batting .241 with 22 doubles, 13 home runs and 30 walks.
• Wade Meckler is batting .298 with 14 doubles, three home runs and 32 walks.

Mariners vs Angels Head to Head

• 9/24/2026: 6-4 LAA (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/16/2026: 7-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/15/2026: 2-1 LAA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/14/2026: 6-4 LAA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/2/2026: 1-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/30/2026: 8-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/29/2026: 6-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/5/2026: 8-7 LAA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/4/2026: 1-0 LAA (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/3/2026: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)

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