Padres vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 7

Odds updated as of 5:11 a.m.

Thursday's slate in the MLB includes a matchup between the San Diego Padres and the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Padres vs Cardinals Game Info

• San Diego Padres (22-14) vs. St. Louis Cardinals (21-15)
• Date: Thursday, May 7, 2026
• Time: 10:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: ESPN

Padres vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-178) | STL: (+150)
• Spread: SD: -1.5 (+126) | STL: +1.5 (-152)
• Total: 8 -- Over: (-110) | Under: (-110)

Padres vs Cardinals Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 3-2, 2.95 ERA vs Matthew Liberatore (Cardinals) - 1-1, 4.50 ERA

This contest's pitching matchup is set, as the Padres will send Michael King (3-2) to the mound, while Matthew Liberatore (1-1) will answer the bell for the Cardinals. King and his team are 2-5-0 ATS this season when he starts. King's team has been victorious in 40% of the games he's started as the moneyline favorite with a record of 2-3. The Cardinals have gone 4-3-0 ATS in Liberatore's seven starts with a set spread. The Cardinals have been the underdog on the moneyline in seven of Liberatore's starts this season, and they went 5-2 in those games.

Padres vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.9%)

Padres vs Cardinals Moneyline

• The moneyline numbers for Padres vs. Cardinals reveal San Diego as the favorite (-178) and St. Louis as the underdog (+150) on the road.

Padres vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Padres. The Cardinals are -152 to cover, and the Padres are +126.

Padres vs Cardinals Over/Under

• Padres versus Cardinals on May 7 has an over/under of 8 runs, with the odds on the over -110 and the under set at -110.

Bet on San Diego Padres vs. St. Louis Cardinals on FanDuel today!

Padres vs Cardinals Betting Trends

• The Padres have been favorites in 20 games this season and have come away with the win 12 times (60%) in those contests.
• This season San Diego has been victorious three times in five chances when named as a favorite of at least -178 on the moneyline.
• Contests with the Padres have gone over the total set by oddsmakers in 16 of 36 chances this season.
• The Padres are 21-15-0 against the spread in their 36 games with a line set by sportsbooks this season.
• The Cardinals have put together a 19-13 record in games they were the underdog on the moneyline (winning 59.4% of those games).
• St. Louis has played as a moneyline underdog of +150 or longer in only two games this season, which it split 1-1.
• The Cardinals have played in 36 games with a set over/under, and have combined with their opponents to go over the total 18 times (18-15-3).
• The Cardinals have gone 22-14-0 ATS this season.

Padres Player Leaders

• Xander Bogaerts has 35 hits and an OBP of .357 to go with a slugging percentage of .457. All three of those stats rank first among San Diego hitters this season. He has a .276 batting average, as well.
• Among qualifying hitters in the majors, he is 46th in batting average, 54th in on-base percentage, and 49th in slugging.
• Bogaerts has recorded at least one hit in two games in a row. In his last five games he is batting .333 with two home runs, two walks and five RBIs.
• Jackson Merrill has eight doubles, four home runs and 11 walks. He's batting .235 and slugging .382 with an on-base percentage of .297.
• His batting average is 114th among qualified players, his on-base percentage 139th, and his slugging percentage 112th.
• Merrill takes a five-game streak with at least one hit into this one. In his last five games he is batting .429 with two doubles, a home run, a walk and three RBIs.
• Manny Machado is batting .207 with a .364 slugging percentage and 18 RBI this year.
• Ramon Laureano has five home runs, 19 RBI and a batting average of .234 this season.

Cardinals Player Leaders

• Jordan Walker has accumulated a team-best slugging percentage (.576) while leading the Cardinals in hits (40). He's batting .303 and with an on-base percentage of .380.
• Including all the qualified hitters in MLB, he is 22nd in batting average, 29th in on-base percentage and eighth in slugging percentage.
• Alec Burleson has nine doubles, five home runs and 17 walks while batting .268. He's slugging .442 with an on-base percentage of .346.
• Including all qualifying hitters, his batting average puts him 55th, his on-base percentage ranks 66th, and he is 57th in slugging.
• JJ Wetherholt is hitting .239 with five doubles, seven home runs and 18 walks.
• Ivan Herrera has a .406 on-base percentage to pace his team.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!