Padres vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for NLDS Game 4 on Oct. 7

Odds updated as of 9:11 a.m.

The Wednesday slate in the MLB includes a matchup between the San Diego Padres and the Milwaukee Brewers for Game 4 of the NLDS.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Padres vs Brewers Game Info

• San Diego Padres (91-71) vs. Milwaukee Brewers (103-59)
• Date: Wednesday, October 7, 2026
• Time: 10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Fox Sports 1

Padres vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-112) | MIL: (-104)
• Spread: SD: +1.5 (-205) | MIL: -1.5 (+168)
• Total: 7.5 -- Over: (+100) | Under: (-122)

Padres vs Brewers Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 9-6, 4.63 ERA vs TBA (Brewers)

The Padres will give the ball to Walker Buehler (9-6, 4.63 ERA), while the Brewers' starter has not yet been announced. Buehler's team is 24-8-0 against the spread this season in his starts. Buehler's team has a record of 10-4 this season when he starts and they are the favorite on the moneyline.

Padres vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (51.9%)

Padres vs Brewers Moneyline

• Looking at the moneyline for Padres-Brewers, San Diego is the favorite at -112, and Milwaukee is -104 playing on the road.

Padres vs Brewers Spread

• The Brewers are 1.5-run favorites against the spread for this matchup with the Padres. The Brewers are +168 to cover, while the Padres are -205 to cover as a 1.5-run underdog on the runline.

Padres vs Brewers Over/Under

• The over/under for Padres-Brewers on Oct. 7 is 7.5. The over is +100, and the under is -122.

Bet on San Diego Padres vs. Milwaukee Brewers on FanDuel today!

Padres vs Brewers Betting Trends

• The Padres have been chosen as favorites in 83 games this year and have walked away with the win 52 times (62.7%) in those games.
• San Diego has a record of 51-29 in contests when bookmakers favor them by -112 or more on the moneyline.
• The Padres and their opponents have gone over the total this season in 78 of their 167 opportunities.
• The Padres are 98-69-0 against the spread in their 167 games that had a posted line this season.
• The Brewers have a 17-17 record in games they were the underdog on the moneyline (winning 50% of those games).
• When playing as a moneyline underdog with odds of -104 or longer, Milwaukee has a record of 12-14 (46.2%).
• The Brewers have played in 164 games with an over/under set, and have combined with opponents to go over the total 71 times (71-88-5).
• The Brewers have covered 51.8% of their games this season, going 85-79-0 ATS.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in slugging percentage (.470) thanks to 60 extra-base hits. He has a .289 batting average and an on-base percentage of .358.
• He ranks 13th in batting average, 36th in on-base percentage, and 34th in slugging among qualified hitters in MLB.
• Jackson Merrill is batting .254 with 26 doubles, five triples, 26 home runs and 41 walks. He's slugging .440 with an on-base percentage of .303.
• He ranks 74th in batting average, 113th in on-base percentage and 56th in slugging in the majors.
• Merrill has picked up a hit in two straight games. In his last five games he is batting .300 with a walk and two RBIs.
• Manny Machado has collected 128 base hits, an OBP of .303 and a slugging percentage of .407 this season.
• Xander Bogaerts has been key for San Diego with 120 hits, an OBP of .332 plus a slugging percentage of .344.

Brewers Player Leaders

• Brice Turang has racked up a team-best .452 slugging percentage. He's batting .270 with an on-base percentage of .367.
• Including all qualifying hitters in MLB, he is 41st in batting average, 19th in on-base percentage and 47th in slugging percentage.
• William Contreras is batting .270 with 27 doubles, a triple, 18 home runs and 61 walks. He's slugging .417 with an on-base percentage of .341.
• Including all qualified hitters, his batting average places him 41st, his on-base percentage ranks 54th, and he is 77th in slugging.
• Jackson Chourio leads the Brewers with 152 hits.
• Jake Bauers paces his team with a .389 OBP.

Padres vs Brewers Head to Head

• 10/6/2026: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +124)
• 10/4/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +116)
• 10/3/2026: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -200, Underdog Moneyline: +180)
• 8/12/2026: 4-3 SD (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: +108)
• 8/11/2026: 11-2 SD (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/10/2026: 3-2 SD (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 5/14/2026: 7-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/13/2026: 3-1 SD (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/12/2026: 6-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/24/2025: 3-1 MIL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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