White Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for ALDS Game 3 on Oct. 7

Odds updated as of 2:11 a.m.

On Wednesday in the MLB, the Chicago White Sox are up against the Cleveland Guardians for Game 3 of the ALDS.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

White Sox vs Guardians Game Info

• Chicago White Sox (84-78) vs. Cleveland Guardians (85-77)
• Date: Wednesday, October 7, 2026
• Time: 4 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: TBS, truTV, and HBO Max

White Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-120) | CLE: (+102)
• Spread: CHW: +1.5 (-215) | CLE: -1.5 (+176)
• Total: 7.5 -- Over: (-120) | Under: (-102)

White Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: Sean Newcomb (White Sox) - 2-5, 3.09 ERA vs Daniel Espino (Guardians) - 0-0, 4.11 ERA

The probable pitchers are Sean Newcomb (2-5, 3.09 ERA) for the White Sox and Daniel Espino for the Guardians. Newcomb's team is 4-2-0 against the spread this season in his starts. Newcomb has yet to start a game this season when his team was the moneyline favorite. The Guardians have a 2-1-0 record against the spread in Espino's starts. The Guardians were named the moneyline underdog for one Espino start this season -- they won.

White Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (56%)

White Sox vs Guardians Moneyline

• Chicago is the favorite, -120 on the moneyline, while Cleveland is a +102 underdog on the road.

White Sox vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the White Sox. The Guardians are +176 to cover, while the White Sox are -215 to cover as a 1.5-run underdog on the runline.

White Sox vs Guardians Over/Under

• A combined run total of 7.5 has been set for White Sox-Guardians on Oct. 7, with the over at -120 and the under at -102.

Bet on Chicago White Sox vs. Cleveland Guardians on FanDuel today!

White Sox vs Guardians Betting Trends

• The White Sox have come away with 26 wins in the 46 contests they have been listed as the favorites in this season.
• This year Chicago has won 19 of 33 games when listed as at least -120 on the moneyline.
• Contests with the White Sox have gone over the total set by sportsbooks in 92 of 163 chances this season.
• In 163 games with a line this season, the White Sox have a mark of 94-69-0 against the spread.
• The Guardians have won 30 of the 59 games they were the underdog on the moneyline this season (50.8%).
• Cleveland has a record of 24-23 in games it has played as a moneyline underdog with odds of +102 or longer (51.1%).
• The Guardians have played in 154 games with a set over/under, and have combined with their opponents to go over the total 75 times (75-79-0).
• The Guardians have covered 47.4% of their games this season, going 73-81-0 ATS.

White Sox Player Leaders

• Miguel Vargas is hitting .250 with 31 doubles, a triple, 33 home runs and 101 walks. He has an on-base percentage of .363 while slugging .474.
• Among the qualified hitters in MLB, his batting average ranks 79th, his on-base percentage ranks 24th, and he is 30th in slugging.
• Vargas hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .133 with eight walks.
• Chase Meidroth has hit 16 homers this season while driving in 63 runs. He's batting .276 this season and slugging .415 with an on-base percentage of .350.
• He ranks 33rd in batting average, 45th in on-base percentage and 80th in slugging among qualifying hitters.
• Sam Antonacci leads Chicago in OBP (.370) this season, fueled by 133 hits.
• Munetaka Murakami leads Chicago with 94 hits, batting .207 this season with 52 extra-base hits.
• Murakami enters this game on a two-game hitting streak. In his last five games he is hitting .250 with a double, a home run, a walk and four RBIs.

Guardians Player Leaders

• Chase DeLauter is leading the Guardians with 142 hits. He's batting .287 and slugging .457 with an on-base percentage of .363.
• Including all qualified hitters, he ranks 16th in batting average, while his on-base percentage is 24th and he is 43rd in slugging.
• Steven Kwan's .382 OBP and .349 slugging percentage both lead his team. He has a batting average of .282.
• His batting average ranks 21st among all qualified players, his on-base percentage is seventh, and he is 131st in slugging.
• Jose Ramirez has 27 doubles, 12 home runs and 60 walks while hitting .235.
• Brayan Rocchio is batting .253 with 25 doubles, two triples, 15 home runs and 38 walks.

White Sox vs Guardians Head to Head

• 10/5/2026: 4-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +136)
• 10/3/2026: 3-0 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +128)
• 9/16/2026: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/15/2026: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)

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