Orioles vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 4:16 a.m.

MLB action on Tuesday includes the Baltimore Orioles facing the Washington Nationals.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Nationals Game Info

• Baltimore Orioles (9-12) vs. Washington Nationals (9-13)
• Date: Tuesday, April 22, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and MASN2

Orioles vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-132) | WSH: (+112)
• Spread: BAL: -1.5 (+116) | WSH: +1.5 (-140)
• Total: 9 -- Over: (-110) | Under: (-110)

Orioles vs Nationals Probable Starting Pitchers

Probable Pitchers: Dean Kremer (Orioles) - 2-2, 6.41 ERA vs Mitchell Parker (Nationals) - 2-1, 1.85 ERA

The probable pitchers are Dean Kremer (2-2) for the Orioles and Mitchell Parker (2-1) for the Nationals. Kremer's team is 2-2-0 against the spread in his starts this season. Kremer's team is 1-1 this season when he starts and they're favored on the moneyline. When Parker starts, the Nationals are 3-1-0 against the spread. The Nationals have a 2-1 record in Parker's three starts this season when they were the underdog on the moneyline.

Orioles vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (59.4%)

Orioles vs Nationals Moneyline

• Washington is a +112 underdog on the moneyline, while Baltimore is a -132 favorite on the road.

Orioles vs Nationals Spread

• The Orioles are at the Nationals and are favored by 1.5 runs (+116 to cover) on the runline. Washington is -140 to cover.

Orioles vs Nationals Over/Under

• The over/under for Orioles-Nationals on April 22 is 9. The over is -110, and the under is -110.

Bet on Baltimore Orioles vs. Washington Nationals on FanDuel today!

Orioles vs Nationals Betting Trends

• The Orioles have come away with five wins in the 12 contests they have been listed as the favorites in this season.
• Baltimore has a record of 1-4 in contests when bookmakers favor them by -132 or more on the moneyline.
• The Orioles and their opponents have hit the over in 14 of their 21 games with a total set by oddsmakers this season.
• The Orioles are 8-13-0 against the spread in their 21 games with a line set by sportsbooks this season.
• The Nationals have won 41.2% of the games this season they were the moneyline underdog (7-10).
• Washington is 4-9 (winning just 30.8% of its games) when playing as a moneyline underdog of +112 or longer.
• The Nationals have combined with opponents to go over the total 12 times this season for a 12-10-0 record against the over/under.
• The Nationals have a 10-12-0 record ATS this season.

Orioles Player Leaders

• Cedric Mullins leads Baltimore with 19 hits and an OBP of .429, plus a team-best slugging percentage of .627. He's batting .284.
• He ranks 50th in batting average, fifth in on-base percentage, and seventh in slugging among qualifying hitters in MLB.
• Mullins has recorded at least one hit in three straight games. During his last five outings he is batting .235 with a double, two home runs, five walks and two RBI.
• Adley Rutschman is batting .208 with two doubles, four home runs and 10 walks, while slugging .390 with an on-base percentage of .299.
• Among qualifiers, he is 131st in batting average, 113th in on-base percentage and 92nd in slugging percentage.
• Ryan O'Hearn has 16 hits this season and has a slash line of .296/.377/.519.
• Heston Kjerstad is batting .261 with a .300 OBP and 12 RBI for Baltimore this season.

Nationals Player Leaders

• James Wood leads the Nationals with 19 hits. He's batting .232 and slugging .524 with an on-base percentage of .337.
• Including all qualified hitters in the big leagues, he ranks 99th in batting average, 75th in on-base percentage and 27th in slugging percentage.
• Keibert Ruiz is hitting .306 with two doubles, two home runs and four walks. He's slugging .417 with an on-base percentage of .359.
• He ranks 26th in batting average, 49th in on-base percentage and 83rd in slugging percentage in the big leagues.
• Nate Lowe has accumulated an on-base percentage of .375 and a slugging percentage of .474. Both lead the Nationals.
• Alex Call is hitting .293 with two doubles, a triple and 10 walks.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!