Notre Dame vs Purdue Prediction, Odds, Picks, Best Bets for Week 4 2026

The Notre Dame Fighting Irish are among the college football squads busy on Saturday, up against the Purdue Boilermakers.

We've got you covered, in terms of the vital info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Notre Dame vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-7143) | Purdue: (+2000)
• Spread: Notre Dame: -27.5 (-118) | Purdue: +27.5 (-104)
• Total: 58.5 -- Over: (-106) | Under: (-114)

Notre Dame vs Purdue Betting Trends

• Notre Dame has won twice against the spread this year.
• As a 27.5-point or greater favorite, Notre Dame has one win ATS (1-1) this season.
• One of Notre Dame's three games this season has gone over the point total.
• Purdue has posted one win against the spread this year.
• Purdue and its opponent have yet to not hit the over this year.

Notre Dame vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (96.1%)

Notre Dame vs Purdue Point Spread

Purdue is listed as an underdog by 27.5 points (-104 odds), and Notre Dame, the favorite, is -118 to cover.

Notre Dame vs Purdue Over/Under

A total of 58.5 points has been set for the Notre Dame-Purdue game on Sept. 26, with the over available at -106 and the under at -114.

Notre Dame vs Purdue Moneyline

Notre Dame is a -7143 favorite on the moneyline, while Purdue is a +2000 underdog.

Notre Dame vs. Purdue Points Insights

Notre Dame vs. Purdue Game Info

• Game day: Saturday, September 26, 2026
• Game time: 2 p.m. ET
• TV channel: Peacock
• Location: West Lafayette, Indiana
• Stadium: Ross-Ade Stadium

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Check out even more in-depth Notre Dame vs. Purdue analysis on FanDuel Research.