Orioles vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 4:12 p.m.

Wednesday's slate in the MLB includes a matchup between the Baltimore Orioles and the Toronto Blue Jays.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Blue Jays Game Info

• Baltimore Orioles (76-81) vs. Toronto Blue Jays (77-80)
• Date: Wednesday, September 23, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SNET

Orioles vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-126) | TOR: (+108)
• Spread: BAL: -1.5 (+172) | TOR: +1.5 (-210)
• Total: 7.5 -- Over: (+116) | Under: (-142)

Orioles vs Blue Jays Probable Starting Pitchers

Probable Pitchers: TBA (Orioles) vs TBA (Blue Jays)

As of this writing, a starting pitcher has yet to be named by either club.

Orioles vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (52.2%)

Orioles vs Blue Jays Moneyline

• Baltimore is a -126 favorite on the moneyline, while Toronto is a +108 underdog on the road.

Orioles vs Blue Jays Spread

• The Orioles are hosting the Blue Jays and are favored by 1.5 runs (+172 to cover) on the runline. Toronto is -210 to cover.

Orioles vs Blue Jays Over/Under

• Orioles versus Blue Jays on Sept. 23 has an over/under of 7.5 runs, with the odds on the over +116 and the under set at -142.

Bet on Baltimore Orioles vs. Toronto Blue Jays on FanDuel today!

Orioles vs Blue Jays Betting Trends

• The Orioles have been favorites in 68 games this season and have come away with the win 36 times (52.9%) in those contests.
• Baltimore has a record of 24-23 when favored by -126 or more this year.
• The Orioles and their opponents have hit the over in 79 of their 155 games with a total set by oddsmakers this season.
• The Orioles are 81-74-0 against the spread in their 155 games that had a posted line this season.
• The Blue Jays have won 43.5% of the games this season they were the moneyline underdog (30-39).
• Toronto has gone 17-23 in games it has played as a moneyline underdog with odds of +108 or longer (42.5%).
• The Blue Jays have had an over/under set by oddsmakers 152 times, and have combined with opponents to go over the total in 80 of those games (80-70-2).
• The Blue Jays have covered 48.7% of their games this season, going 74-78-0 ATS.

Orioles Player Leaders

• Pete Alonso has 156 hits and an OBP of .359 to go with a slugging percentage of .510. All three of those stats are best among Baltimore hitters this season. He has a .265 batting average, as well.
• Among all qualifying hitters, he is 50th in batting average, his on-base percentage ranks 31st, and he is 11th in slugging.
• Gunnar Henderson is batting .227 with 27 doubles, six triples, 24 home runs and 65 walks, while slugging .408 with an on-base percentage of .310.
• He is 119th in batting average, 103rd in on-base percentage and 83rd in slugging among qualified hitters.
• Coby Mayo has 90 hits this season and has a slash line of .227/.295/.466.
• Leody Taveras has been key for Baltimore with 91 hits, an OBP of .286 plus a slugging percentage of .339.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has racked up an on-base percentage of .336, a team-high for the Blue Jays. He's batting .263 and slugging .359.
• Including all the qualifying hitters in the big leagues, he ranks 55th in batting average, 60th in on-base percentage and 121st in slugging percentage.
• Guerrero brings a four-game hitting streak into this matchup. In his last five games he is hitting .267 with three walks.
• Kazuma Okamoto leads his team with 130 hits. He has a batting average of .235 while slugging .458 with an on-base percentage of .310.
• Including all qualified players, his batting average places him 103rd, his on-base percentage ranks 103rd, and he is 38th in slugging.
• Ernie Clement has racked up a team-high .370 slugging percentage.
• George Springer has 22 doubles, two triples, 15 home runs and 47 walks while hitting .251.

Orioles vs Blue Jays Head to Head

• 9/13/2026: 8-1 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/12/2026: 7-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/11/2026: 7-4 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/7/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/6/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/5/2026: 13-3 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/31/2026: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/30/2026: 6-5 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/29/2026: 6-5 TOR (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/28/2026: 2-1 TOR (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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