NFL Games This Sunday: Predictions, Odds, Picks, Best Bets for Week 3

There is no shortage of excitement on the Week 3 NFL schedule's Sunday slate, including the New England Patriots taking on the Jacksonville Jaguars.

Here is what you need to know regarding the betting odds for Sunday.

Commanders vs. Seahawks

After a 31-7 victory against the Cardinals in their last game, the Seattle Seahawks (2-0) will visit the Washington Commanders (0-2), who are coming off a 37-20 loss to the Cowboys. The game is scheduled for 1 p.m. ET on Sunday, Sept. 27.

• Game Preview: Seattle Seahawks at Washington Commanders
• Projected Favorite: Seahawks (70.78% win probability)
• Spread: Seattle (-7)
• Total: 40.5 -- Over: (-108) | Under: (-112)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Washington vs. Seattle with FanDuel Sportsbook.

Steelers vs. Bengals

After a 20-6 victory over the Texans in their last game, the Cincinnati Bengals (2-0) will visit the Pittsburgh Steelers (1-1), who are coming off a 20-3 loss to the Patriots. The game is set for 1 p.m. ET on Sunday, Sept. 27.

• Game Preview: Cincinnati Bengals at Pittsburgh Steelers
• Projected Favorite: Bengals (51.00% win probability)
• Spread: Cincinnati (-3.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Pittsburgh vs. Cincinnati with FanDuel Sportsbook.

Colts vs. Texans

At Lucas Oil Stadium on Sunday, Dalton Schultz and the Houston Texans (0-2) meet Jonathan Taylor and the Indianapolis Colts (0-2) in a matchup between two of the brightest stars in football, beginning at 1 p.m. ET.

• Game Preview: Houston Texans at Indianapolis Colts
• Projected Favorite: Colts (51.01% win probability)
• Spread: Houston (-2.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Houston with FanDuel Sportsbook.

Dolphins vs. Chiefs

After a 33-30 victory against the Colts in their previous game, the Kansas City Chiefs (2-0) will visit the Miami Dolphins (0-2), who are coming off a 35-13 loss to the 49ers. The game is scheduled for 1 p.m. ET on Sunday, Sept. 27.

• Game Preview: Kansas City Chiefs at Miami Dolphins
• Projected Favorite: Chiefs (70.15% win probability)
• Spread: Kansas City (-10.5)
• Total: 45.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Miami vs. Kansas City with FanDuel Sportsbook.

Bills vs. Chargers

The Buffalo Bills (2-0), who defeated the Lions in their previous game, host the Los Angeles Chargers (0-2) at New Highmark Stadium on Sept. 27 at 1 p.m. ET. The Chargers lost to the Raiders in their last game.

• Game Preview: Los Angeles Chargers at Buffalo Bills
• Projected Favorite: Bills (77.34% win probability)
• Spread: Buffalo (-7.5)
• Total: 50.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Buffalo vs. Los Angeles with FanDuel Sportsbook.

Giants vs. Titans

Isaiah Likely will lead the New York Giants (1-1) into their matchup versus the Tennessee Titans (0-2) at MetLife Stadium on Sunday at 1 p.m. ET.

• Game Preview: Tennessee Titans at New York Giants
• Projected Favorite: Giants (66.24% win probability)
• Spread: New York (-2.5)
• Total: 39.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Tennessee with FanDuel Sportsbook.

Lions vs. Jets

When the Detroit Lions (1-1) and the New York Jets (1-1) match up on Sunday, Sept. 27 at 1 p.m. ET, they will both be looking to right the ship after losing their previous contest. The Lions lost 41-31 to the Bills, and the Jets are coming off a 20-17 loss to the Packers.

• Game Preview: New York Jets at Detroit Lions
• Projected Favorite: Lions (84.49% win probability)
• Spread: Detroit (-6.5)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Detroit vs. New York with FanDuel Sportsbook.

Browns vs. Panthers

When the Carolina Panthers (1-1) and the Cleveland Browns (1-1) play on Sunday, Sept. 27 at 1 p.m. ET, they will both be looking to build momentum after winning their last game. The Panthers won 34-3 against the Falcons, and the Browns are coming off a 23-19 victory over the Buccaneers.

• Game Preview: Carolina Panthers at Cleveland Browns
• Projected Favorite: Panthers (54.38% win probability)
• Spread: Carolina (-2.5)
• Total: 41.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cleveland vs. Carolina with FanDuel Sportsbook.

Jaguars vs. Patriots

The Jacksonville Jaguars (1-1) play on Sunday at 1 p.m. ET against the New England Patriots (1-1) at EverBank Stadium.

• Game Preview: New England Patriots at Jacksonville Jaguars
• Projected Favorite: Jaguars (60.40% win probability)
• Spread: Jacksonville (-2.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. New England with FanDuel Sportsbook.

49ers vs. Cardinals

At Levi's Stadium on Sunday, Brock Purdy and the San Francisco 49ers (2-0) play Trey McBride and the Arizona Cardinals (1-1) in a battle featuring two of the brightest stars in football, starting at 4:05 p.m. ET.

• Game Preview: Arizona Cardinals at San Francisco 49ers
• Projected Favorite: 49ers (80.68% win probability)
• Spread: San Francisco (-8.5)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Arizona with FanDuel Sportsbook.

Buccaneers vs. Vikings

When the Minnesota Vikings (2-0) and the Tampa Bay Buccaneers (0-2) go head to head on Sunday, Sept. 27 at 4:05 p.m. ET, the Vikings will be looking to follow up their recent victory over the Bears with another win, and the Buccaneers will be trying to rebound from a loss to the Browns.

• Game Preview: Minnesota Vikings at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (52.07% win probability)
• Spread: Minnesota (-1.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. Minnesota with FanDuel Sportsbook.

Saints vs. Raiders

After claiming a 24-17 win versus the Ravens in their last contest, the New Orleans Saints (1-1) will host the Las Vegas Raiders (2-0), who are coming off a 26-14 win over the Chargers, at Caesars Superdome. Kickoff is slated for 4:25 p.m. ET on Sunday, Sept. 27.

• Game Preview: Las Vegas Raiders at New Orleans Saints
• Projected Favorite: Saints (72.97% win probability)
• Spread: New Orleans (-3)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on New Orleans vs. Las Vegas with FanDuel Sportsbook.

Cowboys vs. Ravens

At Maracanã Stadium on Sunday, Derrick Henry and the Baltimore Ravens (1-1) play CeeDee Lamb and the Dallas Cowboys (1-1) in a battle between two of the biggest stars in football offensively, beginning at 4:25 p.m. ET.

• Game Preview: Baltimore Ravens vs. Dallas Cowboys
• Projected Favorite: Ravens (59.54% win probability)
• Spread: Baltimore (-3.5)
• Total: 52.5 -- Over: (-108) | Under: (-112)
• Time: 4:25 p.m. ET
• Channel: CBS/Paramount+

Bet on Dallas vs. Baltimore with FanDuel Sportsbook.

Broncos vs. Rams

One of the top pass-catchers in football will be on display when Davante Adams and the Los Angeles Rams (1-1) visit the Denver Broncos (1-1) on Sunday, September 27, 2026.

• Game Preview: Los Angeles Rams at Denver Broncos
• Projected Favorite: Rams (51.84% win probability)
• Spread: Los Angeles (-2.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Denver vs. Los Angeles with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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