Louisville vs Ole Miss Prediction College Football Best Bets, Picks, Odds and Player Props

College Football Betting Picks & Player Props in Summary

• Ole Miss -6.5
• Over 55.5
• Ole Miss Team Total Over 31.5
• Trinidad Chambliss 275+ Passing Yards
• Johntay Cook II 40+ Receiving Yards

No. 24 Louisville travels to No. 9 Ole Miss Sunday night in genuinely the most competitive matchup of the entire weekend — a modest 6.5-point spread between two ranked teams, backed by one of the higher totals on the board.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

Louisville at Ole Miss (Sun, 7:30 p.m. ET)

Ole Miss -6.5 (-118)

Ole Miss's own projected yardage output (427.5) sits comfortably ahead of Louisville's (371.5), and its own team total (31.5) is a full touchdown clear of the visitors' (23.5) — a real, well-supported edge for the home favorite in a genuinely competitive spot.

Over 55.5 (-105)

The two team totals combine to 55 points on their own, essentially matching this number exactly — a genuinely fair reflection of how the market expects the scoring to actually break down between two productive offenses.

Ole Miss Team Total Over 31.5 (-102)

Right around even money for the home favorite to clear its own number, consistent with both the spread and Trinidad Chambliss's confirmed passing volume behind him.

Best Player Props

Trinidad Chambliss 275+ Passing Yards (-105)

Chambliss's own market shows real confidence in a big passing day, priced near even money even at this high a yardage threshold — a genuine sign Ole Miss plans to let him throw against a Louisville defense that's expected to keep it competitive.

Johntay Cook II 40+ Receiving Yards (-120)

Cook's pricing across every threshold points to him as Louisville's clear top receiving option, and with the Cardinals needing to keep pace on the scoreboard, a real path to 40-plus yards looks well within reach even on the road.