Louisville vs Ole Miss Prediction: 5 College Football Best Bets and Player Props Today

College Football Betting Picks & Player Props in Summary

• Ole Miss -6.5
• Over 54.5
• Ole Miss Over 425.5 Total Yards
• Trinidad Chambliss 275+ Passing Yards
• Deuce Alexander 40+ Receiving Yards

No. 24 Louisville travels to No. 9 Ole Miss Sunday night in genuinely the most competitive matchup of the entire weekend — a modest 6.5-point spread between two ranked teams, backed by one of the higher totals on the board.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

Louisville at Ole Miss (Sun, 7:30 p.m. ET)

Ole Miss -6.5 (-118)

Ole Miss's own projected yardage output (425.5) sits comfortably ahead of Louisville's (370.5), a modest but real edge that lines up with the home favorite number in a genuinely competitive spot.

Over 54.5 (-115)

Both offenses carry real, sizable yardage projections — a combined 796 yards between the two team totals — pointing toward a genuine back-and-forth scoring game between two ranked opponents.

Ole Miss Over 425.5 Total Yards (-114)

Ole Miss's rushing attack alone is projected for 137.5 yards, meaning the passing game only needs to contribute another 288 or so to clear this number — a reasonable ask behind a real starting quarterback.

Best Player Props

Trinidad Chambliss 275+ Passing Yards (-110)

Chambliss's own market shows real confidence in a big passing day, with his price sitting at close to even odds even at this high a yardage threshold — a genuine indicator Ole Miss plans to let him throw against a Louisville defense that's expected to keep it competitive.

Deuce Alexander 40+ Receiving Yards (-270)

Alexander's pricing across every threshold points to him being Ole Miss's clear top receiving option tonight, and with Chambliss expected to throw plenty, a real path to 40-plus yards looks well within reach.