Louisiana Tech vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 4 2025

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College football's Saturday schedule includes the Louisiana Tech Bulldogs taking on the Southern Miss Golden Eagles.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Louisiana Tech vs Southern Miss Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Louisiana Tech: (-162) | Southern Miss: (+134)
Spread: Louisiana Tech: -3.5 (-105) | Southern Miss: +3.5 (-115)
Total: 50.5 -- Over: (-114) | Under: (-106)

Louisiana Tech's record against the spread is 3-0-0.
Louisiana Tech has yet to lose ATS (2-0) as a 3.5-point favorite or greater this year.
One of three Louisiana Tech games have gone over the point total this year.
Southern Miss has won twice against the spread this season.
As a 3.5-point underdog or greater, Southern Miss has one win ATS (1-1) this year.
Two Southern Miss games (of three) have gone over the point total this year.

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulldogs win (74%)

Southern Miss is listed as an underdog by 3.5 points (-115 odds), and Louisiana Tech, the favorite, is -105 to cover.

A combined point total of 50.5 has been set for Louisiana Tech-Southern Miss on Sept. 20, with the over at -114 and the under at -106.

Southern Miss is a +134 underdog on the moneyline, while Louisiana Tech is a -162 favorite.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Louisiana Tech	26.7	78	12.3	27	47.2	3
Southern Miss	31.0	61	25.3	93	56.5	3

Check out even more in-depth Louisiana Tech vs. Southern Miss analysis on FanDuel Research.

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