Iowa State vs Arkansas State Prediction, Odds, Picks, Best Bets for Week 3 2025

Saturday's slate in college football includes a matchup between the Iowa State Cyclones and the Arkansas State Red Wolves.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info about today's NCAA football betting odds.

Iowa State vs Arkansas State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-2500) | Arkansas State: (+1100)
• Spread: Iowa State: -21.5 (-115) | Arkansas State: +21.5 (-105)
• Total: 55.5 -- Over: (-110) | Under: (-110)

Iowa State vs Arkansas State Betting Trends

• Iowa State has posted two wins against the spread this season.
• One of three Iowa State games have gone over the point total this year.
• Arkansas State has one win against the spread this year.
• Arkansas State doesn't have a win ATS (0-1) as a 21.5-point underdog or more this season.
• Arkansas State has played two games (out of two) which finished over the total this year.

Iowa State vs Arkansas State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (91.9%)

Iowa State vs Arkansas State Point Spread

Iowa State is favored by 21.5 points against Arkansas State. Iowa State is -115 to cover the spread, while Arkansas State is -105.

Iowa State vs Arkansas State Over/Under

Iowa State versus Arkansas State, on Sept. 13, has an over/under of 55.5, with the over being -110 and the under -110.

Iowa State vs Arkansas State Moneyline

Iowa State is the favorite, -2500 on the moneyline, while Arkansas State is a +1100 underdog.

Iowa State vs. Arkansas State Points Insights

Iowa State vs. Arkansas State Game Info

• Game day: Saturday, September 13, 2025
• Game time: 4 p.m. ET
• TV channel: ESPN2
• Location: Jonesboro, Arkansas
• Stadium: Centennial Bank Stadium

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Check out even more in-depth Iowa State vs. Arkansas State analysis on FanDuel Research.