Indiana vs Illinois Prediction, Odds, Picks, Best Bets for Week 4 2025

Saturday's slate in college football includes a matchup between the Indiana Hoosiers and the Illinois Fighting Illini.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Indiana vs Illinois Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Indiana: (-230) | Illinois: (+188)
• Spread: Indiana: -6.5 (-108) | Illinois: +6.5 (-112)
• Total: 52.5 -- Over: (-110) | Under: (-110)

Indiana vs Illinois Betting Trends

• Indiana has won twice against the spread this season.
• Indiana has won twice ATS (2-1) as a 6.5-point or bigger favorite this season.
• Indiana has had two games (out of three) hit the over this season.
• Illinois' record against the spread in 2025 is 3-0-0.
• One of Illinois' three games has gone over the point total.

Indiana vs Illinois Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hoosiers win (82.3%)

Indiana vs Illinois Point Spread

Indiana is a 6.5-point favorite against Illinois. Indiana is -108 to cover the spread, and Illinois is -112.

Indiana vs Illinois Over/Under

A combined point total of 52.5 has been set for Indiana-Illinois on Sept. 20, with the over at -110 and the under at -110.

Indiana vs Illinois Moneyline

Indiana is the favorite, -230 on the moneyline, while Illinois is a +188 underdog.

Indiana vs. Illinois Points Insights

Indiana vs. Illinois Game Info

• Game day: Saturday, September 20, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: Bloomington, Indiana
• Stadium: Memorial Stadium (Bloomington, IN)

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Check out even more in-depth Indiana vs. Illinois analysis on FanDuel Research.