Guardians vs Yankees Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 4:15 a.m.

Tuesday's slate in the MLB includes a matchup between the Cleveland Guardians and the New York Yankees.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Yankees Game Info

• Cleveland Guardians (13-9) vs. New York Yankees (14-9)
• Date: Tuesday, April 22, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and YES

Guardians vs Yankees Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-108) | NYY: (-108)
• Spread: CLE: +1.5 (-178) | NYY: -1.5 (+146)
• Total: 8 -- Over: (-110) | Under: (-110)

Guardians vs Yankees Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 1-2, 5.85 ERA vs Will Warren (Yankees) - 1-0, 5.17 ERA

The Guardians will give the ball to Tanner Bibee (1-2, 5.85 ERA), who is eyeing win No. 2 on the season, and the Yankees will turn to Will Warren (1-0, 5.17 ERA). Bibee and his team are 2-2-0 ATS this season when he starts. Bibee's team is 1-1 this season when he starts and they're favored on the moneyline. The Yankees have a 2-2-0 ATS record in Warren's four starts that had a set spread. The Yankees were named the moneyline underdog for one Warren start this season -- they lost.

Guardians vs Yankees Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.1%)

Guardians vs Yankees Moneyline

• Cleveland is a -108 favorite on the moneyline, while New York is a -108 underdog on the road.

Guardians vs Yankees Spread

Guardians vs Yankees Over/Under

• The over/under for Guardians-Yankees on April 22 is 8. The over is -110, and the under is -110.

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Guardians vs Yankees Betting Trends

• The Guardians have been chosen as favorites in nine games this year and have walked away with the win seven times (77.8%) in those games.
• Cleveland has a record of 7-2 when favored by -108 or more this year.
• The Guardians and their opponents have gone over the total this season in 12 of their 22 opportunities.
• The Guardians have an against the spread record of 10-12-0 in 22 games with a line this season.
• The Yankees have not yet won as the moneyline underdog this season, going 6-7.
• New York has played three times as a moneyline underdog with odds of -108 or longer, and fell in each game.
• The Yankees have played in 23 games with an over/under set, and have combined with opponents to go over the total 12 times (12-9-2).
• The Yankees have an 11-12-0 record against the spread this season.

Guardians Player Leaders

• Steven Kwan leads Cleveland with an OBP of .396, plus a team-best slugging percentage of .506. He's batting .333 on the season.
• He ranks 11th in batting average, 21st in on-base percentage, and 33rd in slugging among all qualified hitters in the majors.
• Kwan has picked up at least one hit in five straight games. In his last five games he is hitting .400 with two doubles, a home run, three walks and three RBI.
• Jose Ramirez is hitting .276 with four doubles, five home runs and eight walks, while slugging .526 with an on-base percentage of .337.
• His batting average ranks 59th among qualified players, his on-base percentage 75th, and his slugging percentage 26th.
• Ramirez heads into this game looking to extend his four-game hit streak. During his last five outings he is batting .300 with a double, a home run, two walks and five RBI.
• Kyle Manzardo has 15 hits and is batting .217 this season.
• Manzardo heads into this game with five games in a row with at least one hit. During his last five outings he is batting .333 with a double, three home runs, two walks and six RBI.
• Gabriel Arias has been key for Cleveland with 19 hits, an OBP of .329 plus a slugging percentage of .493.
• Arias enters this matchup on a three-game hitting streak. In his last five games he is batting .250 with two doubles, a home run, a walk and three RBI.

Yankees Player Leaders

• Aaron Judge has racked up an on-base percentage of .490, a slugging percentage of .698, and has 33 hits, all club-highs for the Yankees (while batting .384).
• Including all qualifying players in the big leagues, he is first in batting average, first in on-base percentage and first in slugging percentage.
• Judge hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .300 with a double, three walks and four RBI.
• Ben Rice is batting .288 with three doubles, a triple, five home runs and 10 walks. He's slugging .591 with an on-base percentage of .397.
• He ranks 41st in batting average, 20th in on-base percentage and 13th in slugging percentage in MLB.
• Anthony Volpe is hitting .217 with five doubles, four home runs and 11 walks.
• Paul Goldschmidt has five doubles, a home run and seven walks while hitting .372.

Guardians vs Yankees Head to Head

• 4/21/2025: 6-4 CLE (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/19/2024: 5-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 10/18/2024: 8-6 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 10/17/2024: 7-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 10/15/2024: 6-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 7, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 10/14/2024: 5-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/22/2024: 6-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/21/2024: 8-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/20/2024: 9-5 CLE (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/14/2024: 8-7 CLE (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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