Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 2:11 a.m.

In MLB action on Friday, the Cleveland Guardians face the Chicago White Sox.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Guardians vs White Sox Game Info

• Cleveland Guardians (75-71) vs. Chicago White Sox (57-90)
• Date: Friday, September 12, 2025
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and CHSN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-174) | CHW: (+146)
• Spread: CLE: -1.5 (+128) | CHW: +1.5 (-154)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 9-11, 4.69 ERA vs Martín Pérez (White Sox) - 1-4, 3.15 ERA

The Guardians will call on Tanner Bibee (9-11) against the White Sox and Martin Perez (1-4). Bibee and his team are 16-11-0 ATS this season when he starts. Bibee's team is 9-5 this season when he starts and they are the moneyline favorite. The White Sox have a 6-2-0 ATS record in Pérez's eight starts that had a set spread. The White Sox have a 3-5 record in Pérez's eight starts this season when they were the underdog on the moneyline.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.8%)

Guardians vs White Sox Moneyline

• Chicago is a +146 underdog on the moneyline, while Cleveland is a -174 favorite at home.

Guardians vs White Sox Spread

• The White Sox are at the Guardians, and are +1.5 on the runline. The White Sox are +128 to cover the spread, and the Guardians are -154.

Guardians vs White Sox Over/Under

• Guardians versus White Sox, on Sept. 12, has an over/under of 7.5, with the over being -115 and the under -105.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have been chosen as favorites in 59 games this year and have walked away with the win 37 times (62.7%) in those games.
• Cleveland has been a -174 moneyline favorite on five occasions this season and won every time.
• The Guardians' games have gone over the total in 63 of their 143 opportunities.
• The Guardians are 76-67-0 against the spread in their 143 games that had a posted line this season.
• The White Sox have a 53-86 record in games they were the underdog on the moneyline (winning 38.1% of those games).
• Chicago has a 21-47 record (winning just 30.9% of its games) when it has played as a moneyline underdog of +146 or longer.
• The White Sox have played in 142 games with an over/under set, and have combined with their opponents to go over the total 67 times (67-67-8).
• The White Sox have covered 57.7% of their games this season, going 82-60-0 against the spread.

Guardians Player Leaders

• Jose Ramirez has 152 hits and an OBP of .358, both of which are best among Cleveland hitters this season. He has a .285 batting average and a slugging percentage of .507.
• Among qualified hitters in the majors, he ranks 17th in batting average, 23rd in on-base percentage, and 16th in slugging.
• Steven Kwan has an OPS of .715, fueled by an OBP of .335 and a team-best slugging percentage of .380 this season. He's batting .276.
• He ranks 30th in batting average, 61st in on-base percentage and 124th in slugging in MLB.
• Kwan brings a two-game streak with at least one hit into this contest. In his last five games he is hitting .300 with a double, three walks and an RBI.
• Kyle Manzardo is batting .240 with a .476 slugging percentage and 67 RBI this year.
• Manzardo has recorded at least one base hit in four straight games. In his last five games he is batting .375 with a double, a home run, three walks and four RBIs.
• Angel Martinez has 10 home runs, 41 RBI and a batting average of .225 this season.

White Sox Player Leaders

• Miguel Vargas has racked up a team-best .316 on-base percentage. He's batting .233 and slugging .401.
• Including all the qualified players in the majors, he is 130th in batting average, 102nd in on-base percentage and 104th in slugging percentage.
• Andrew Benintendi is batting .248 with 16 doubles, two triples, 19 home runs and 37 walks. He's slugging .438 with an on-base percentage of .311.
• Lenyn Sosa has accumulated a slugging percentage of .436 and has 124 hits, both team-high marks for the White Sox.
• Chase Meidroth is hitting .269 with 15 doubles, four home runs and 43 walks.

Guardians vs White Sox Head to Head

• 8/10/2025: 6-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/9/2025: 3-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/8/2025: 9-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/13/2025: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/12/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/11/2025: 5-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/10/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/9/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/8/2025: 1-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)

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