Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for July 10

Odds updated as of 7:12 a.m.

The MLB's Thursday schedule includes the Cleveland Guardians facing the Chicago White Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Guardians vs White Sox Game Info

• Cleveland Guardians (43-48) vs. Chicago White Sox (31-62)
• Date: Thursday, July 10, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and CLEG

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | CHW: (+110)
• Spread: CLE: -1.5 (+130) | CHW: +1.5 (-156)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Logan Allen (Guardians) - 5-7, 4.07 ERA vs Jonathan Cannon (White Sox) - 3-7, 4.50 ERA

The Guardians will give the ball to Logan Allen (5-7, 4.07 ERA), who is eyeing win No. 6 on the season, and the White Sox will counter with Jonathan Cannon (3-7, 4.50 ERA). Allen's team is 6-9-0 against the spread in his starts this season. Allen has started three games with his team as the moneyline favorite and won each of them. The White Sox have gone 5-7-0 ATS in Cannon's 12 starts that had a set spread. The White Sox have a 3-9 record in Cannon's 12 starts this season when they were the underdog on the moneyline.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (52.6%)

Guardians vs White Sox Moneyline

• Chicago is the underdog, +110 on the moneyline, while Cleveland is a -130 favorite despite being on the road.

Guardians vs White Sox Spread

• The White Sox are at +1.5 on the runline against the Guardians. The White Sox are -156 to cover the spread, and the Guardians are +130.

Guardians vs White Sox Over/Under

• A combined run total of 8.5 has been set for Guardians-White Sox on July 10, with the over at -108 and the under at -112.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have been chosen as favorites in 29 games this year and have walked away with the win 17 times (58.6%) in those games.
• Cleveland has a record of 10-4 when favored by -130 or more this year.
• Contests with the Guardians have gone over the total set by oddsmakers in 38 of 89 chances this season.
• The Guardians have an against the spread mark of 45-44-0 in 89 games with a line this season.
• The White Sox have put together a 28-59 record in games they were listed as the moneyline underdog (winning 32.2% of those games).
• Chicago has a 28-55 record (winning just 33.7% of its games) when playing as a moneyline underdog of +110 or longer.
• The White Sox have played in 90 games with a set over/under, and have combined with opponents to go over the total 38 times (38-47-5).
• The White Sox have collected a 48-42-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland in OBP (.366) and total hits (100) this season. He's batting .301 batting average while slugging .512.
• Among qualifying hitters in MLB, his batting average ranks 10th, his on-base percentage ranks 29th, and he is 16th in slugging.
• Ramirez hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .333 with a double, three home runs, four walks and six RBIs.
• Steven Kwan has hit six homers this season while driving in 29 runs. He's batting .292 this season and slugging .408 with an on-base percentage of .350.
• He ranks 16th in batting average, 45th in on-base percentage and 96th in slugging among qualifying hitters.
• Carlos Santana is batting .230 with a .353 slugging percentage and 38 RBI this year.
• Angel Martinez is batting .238 with a .264 OBP and 31 RBI for Cleveland this season.
• Martinez enters this game on a six-game hitting streak. During his last 10 games he is hitting .273 with three doubles, two home runs, three walks and six RBIs.

White Sox Player Leaders

• Miguel Vargas has accumulated an on-base percentage of .301 and has 72 hits, both team-best numbers for the White Sox. He's batting .220 and slugging .388.
• Including all qualifying players in the big leagues, he ranks 143rd in batting average, 130th in on-base percentage and 115th in slugging percentage.
• Andrew Benintendi is batting .223 with 10 doubles, two triples, 10 home runs and 19 walks. He's slugging .415 with an on-base percentage of .282.
• Chase Meidroth has six doubles, two home runs and 31 walks while hitting .247.
• Lenyn Sosa leads his team with a .408 slugging percentage.

Guardians vs White Sox Head to Head

• 4/10/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/9/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/8/2025: 1-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/11/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/10/2024: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/9/2024: 5-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/4/2024: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 7/3/2024: 8-2 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 7/2/2024: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/12/2024: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)

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