Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for ALDS Game 4 on Oct. 8

Odds updated as of 9:12 a.m.

On Thursday in the MLB, the Cleveland Guardians are up against the Chicago White Sox in Game 4 of the ALDS.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Guardians vs White Sox Game Info

• Cleveland Guardians (85-77) vs. Chicago White Sox (84-78)
• Date: Thursday, October 8, 2026
• Time: 8 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: truTV, TBS, and HBO Max

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | CHW: (+100)
• Spread: CLE: -1.5 (+150) | CHW: +1.5 (-182)
• Total: 7.5 -- Over: (+100) | Under: (-122)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 12-9, 2.56 ERA vs Hagen Smith (White Sox) - 3-3, 1.29 ERA

The probable pitchers are Parker Messick (12-9, 2.56 ERA) for the Guardians and Hagen Smith (3-3, 1.29 ERA) for the White Sox. Messick's team is 16-17-0 against the spread in his starts this season. Messick's team has been victorious in 48% of the games he's started as the moneyline favorite with a record of 12-13. The White Sox have gone 2-1-0 ATS in Smith's three starts with a set spread. The White Sox were the moneyline underdog for two Smith starts this season -- they won both.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (50.4%)

Guardians vs White Sox Moneyline

• Looking at the moneyline for Guardians-White Sox, Cleveland is the favorite at -118, and Chicago is +100 playing at home.

Guardians vs White Sox Spread

• The Guardians are 1.5-run road favorites on the runline against the White Sox. The Guardians are +150 to cover, and the White Sox are -182.

Guardians vs White Sox Over/Under

• The over/under for the Guardians versus White Sox contest on Oct. 8 has been set at 7.5, with +100 odds on the over and -122 odds on the under.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have won in 48, or 52.2%, of the 92 contests they have been named as odds-on favorites in this year.
• Cleveland has a record of 41-35 in contests when oddsmakers favor them by -118 or more on the moneyline.
• The Guardians and their opponents have hit the over in 76 of their 155 games with a total set by oddsmakers this season.
• The Guardians have an against the spread record of 74-81-0 in 155 games with a line this season.
• The White Sox have won 49.5% of the games this season they were the moneyline underdog (54-55).
• Chicago has gone 46-47 when it has played as a moneyline underdog with odds of +100 or longer (49.5%).
• The White Sox have played in 164 games with an over/under set, and have combined with opponents to go over the total 93 times (93-70-1).
• The White Sox have collected a 94-70-0 record ATS this season (covering 57.3% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (142) this season while batting .287 with 49 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .457.
• Among qualifying batters, he is 16th in batting average, his on-base percentage ranks 24th, and he is 43rd in slugging.
• DeLauter will look for his third straight game with a hit in this contest. During his last five outings he is batting .250 with a double, a home run, four walks and three RBIs.
• Steven Kwan is slashing .282/.382/.349 this season and leads the Guardians with an OPS of .731.
• He is 21st in batting average, seventh in on-base percentage and 131st in slugging in the majors.
• Kwan takes a two-game streak with at least one hit into this matchup. During his last five outings he is batting .250 with a triple, four walks and two RBIs.
• Jose Ramirez has collected 111 base hits, an OBP of .320 and a slugging percentage of .368 this season.
• Brayan Rocchio has been key for Cleveland with 135 hits, an OBP of .313 plus a slugging percentage of .391.

White Sox Player Leaders

• Miguel Vargas has 31 doubles, a triple, 33 home runs and 101 walks while hitting .250. He's slugging .474 with an on-base percentage of .363.
• Including all qualified hitters, he is 79th in batting average, while his on-base percentage ranks 24th and he is 30th in slugging.
• Vargas takes a three-game hitting streak into this game. In his last five games he is hitting .176 with six walks.
• Chase Meidroth is slugging .415 to lead his team. He has a batting average of .276 with an on-base percentage of .350.
• Including all qualified hitters, he is 33rd in batting average, 45th in on-base percentage and 80th in slugging percentage.
• Sam Antonacci a has .370 on-base percentage to lead the White Sox.
• Munetaka Murakami's 94 hits pace his team.

Guardians vs White Sox Head to Head

• 10/7/2026: 9-3 CLE (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -128, Underdog Moneyline: +112)
• 10/5/2026: 4-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +136)
• 10/3/2026: 3-0 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +128)
• 9/16/2026: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/15/2026: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!