Guardians vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 15

Odds updated as of 1:12 a.m.

Saturday's slate in the MLB includes a matchup between the Cleveland Guardians and the San Diego Padres.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Padres Game Info

• Cleveland Guardians (59-64) vs. San Diego Padres (66-57)
• Date: Saturday, August 15, 2026
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Padres.TV

Guardians vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-120) | SD: (+102)
• Spread: CLE: +1.5 (-210) | SD: -1.5 (+172)
• Total: 8 -- Over: (-115) | Under: (-105)

Guardians vs Padres Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 8-7, 3.91 ERA vs Randy Vasquez (Padres) - 8-6, 4.16 ERA

This contest's pitching matchup is set, as the Guardians will send Joey Cantillo (8-7) to the mound, while Randy Vasquez (8-6) will get the nod for the Padres. Cantillo's team is 15-10-0 against the spread this season in his starts. When Cantillo starts a game and his team is the favorite on the moneyline, they have a record of 6-5. The Padres have a 13-6-0 record against the spread in Vasquez's starts. The Padres have a 5-4 record in Vasquez's nine starts this season when they were the moneyline underdog.

Guardians vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.5%)

Guardians vs Padres Moneyline

• Looking at the moneyline for Guardians-Padres, Cleveland is the favorite at -120, and San Diego is +102 playing on the road.

Guardians vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Guardians. The Padres are +172 to cover, while the Guardians are -210 to cover as a 1.5-run underdog on the runline.

Guardians vs Padres Over/Under

• An over/under of 8 has been set for Guardians-Padres on Aug. 15, with the over being -115 and the under -105.

Bet on Cleveland Guardians vs. San Diego Padres on FanDuel today!

Guardians vs Padres Betting Trends

• The Guardians have been favorites in 66 games this season and have come away with the win 30 times (45.5%) in those contests.
• This season Cleveland has come away with a win 24 times in 51 chances when named as a favorite of at least -120 on the moneyline.
• Contests with the Guardians have gone over the total set by bookmakers in 58 of 117 chances this season.
• In 117 games with a line this season, the Guardians have a mark of 55-62-0 against the spread.
• The Padres have a 34-33 record in games they were the underdog on the moneyline (winning 50.7% of those games).
• When it has played as a moneyline underdog with odds of +102 or longer, San Diego has a 28-27 record (winning 50.9% of its games).
• The Padres have had an over/under set by oddsmakers 123 times, and have combined with opponents to go over the total in 56 of those games (56-65-2).
• The Padres have put together a 70-53-0 record ATS this season (covering 56.9% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 113 hits and a team-best slugging percentage of .442. He's batting .284 with an on-base percentage of .357.
• Among the qualified batters in baseball, his batting average ranks 20th, his on-base percentage ranks 36th, and he is 57th in slugging.
• DeLauter has hit safely in four straight games. During his last five outings he is hitting .364 with a double, a home run, two walks and an RBI.
• Jose Ramirez is hitting .231 with 18 doubles, 10 home runs and 53 walks. He's slugging .377 with an on-base percentage of .338.
• His batting average ranks 115th among qualified players, his on-base percentage 59th, and his slugging percentage 116th.
• Brayan Rocchio has collected 107 base hits, an OBP of .317 and a slugging percentage of .378 this season.
• Rocchio has picked up a hit in three games in a row. During his last five outings he is batting .250 with a double, a home run and an RBI.
• Steven Kwan has 104 hits this season and a team-best OBP of .368.

Padres Player Leaders

• Fernando Tatis Jr. has racked up a team-best OBP (.353) and slugging percentage (.425), and paces the Padres in hits (132, while batting .280).
• Including all the qualifying hitters in the big leagues, his batting average is 26th, his on-base percentage ranks 40th, and he is 72nd in slugging.
• Manny Machado is batting .215 with 20 doubles, 23 home runs and 55 walks. He's slugging .414 with an on-base percentage of .297.
• Including all qualifying players, he is 133rd in batting average, 124th in on-base percentage and 85th in slugging percentage.
• Jackson Merrill has 20 doubles, two triples, 19 home runs and 32 walks while hitting .245.
• Xander Bogaerts is batting .223 with 11 doubles, 11 home runs and 56 walks.

Guardians vs Padres Head to Head

• 8/14/2026: 7-5 SD (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: +106)
• 4/2/2025: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 4/1/2025: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 3/31/2025: 7-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/21/2024: 2-1 SD (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/20/2024: 7-0 SD (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/19/2024: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/14/2023: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/13/2023: 6-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/24/2022: 7-0 CLE (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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