Guardians vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 15

Odds updated as of 6:12 p.m.

MLB action on Saturday includes the Cleveland Guardians playing the San Diego Padres.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Padres Game Info

• Cleveland Guardians (59-64) vs. San Diego Padres (66-57)
• Date: Saturday, August 15, 2026
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Padres.TV

Guardians vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-116) | SD: (+106)
• Spread: CLE: +1.5 (-210) | SD: -1.5 (+172)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Guardians vs Padres Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 8-7, 3.91 ERA vs Wandy Peralta (Padres) - 2-2, 3.39 ERA

The probable pitchers are Joey Cantillo (8-7) for the Guardians and Wandy Peralta (2-2) for the Padres. Cantillo's team is 15-10-0 against the spread in his starts this season. When Cantillo starts a game and his team is the favorite on the moneyline, they have a record of 6-5. The Padres have a 2-2-0 ATS record in Peralta's four starts with a set spread. The Padres have been the moneyline underdog in four of Peralta's starts this season, and they went 1-3 in those matchups.

Guardians vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.4%)

Guardians vs Padres Moneyline

• San Diego is the underdog, +106 on the moneyline, while Cleveland is a -116 favorite at home.

Guardians vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Guardians. The Padres are +172 to cover, while the Guardians are -210 to cover as a 1.5-run underdog on the runline.

Guardians vs Padres Over/Under

• The over/under for the Guardians versus Padres game on Aug. 15 has been set at 8.5, with -110 odds on the over and -110 odds on the under.

Bet on Cleveland Guardians vs. San Diego Padres on FanDuel today!

Guardians vs Padres Betting Trends

• The Guardians have come away with 30 wins in the 66 contests they have been listed as the favorites in this season.
• Cleveland has a record of 29-32 in contests when bookmakers favor them by -116 or more on the moneyline.
• The Guardians and their opponents have gone over in 58 of their 117 games with a total set by sportsbooks this season.
• The Guardians have an against the spread mark of 55-62-0 in 117 games with a line this season.
• The Padres have gone 34-33 in games they were the underdog on the moneyline (winning 50.7% of those games).
• When it has played as a moneyline underdog with odds of +106 or longer, San Diego has a 22-26 record (winning 45.8% of its games).
• The Padres have played in 123 games with an over/under set, and have combined with opponents to go over the total 56 times (56-65-2).
• The Padres have a 70-53-0 record ATS this season (covering 56.9% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 113 hits and a team-best slugging percentage of .442. He's batting .284 with an on-base percentage of .357.
• Among qualifying batters in the majors, he is 19th in batting average, 38th in on-base percentage, and 58th in slugging.
• DeLauter will look for his fifth straight game with a hit in this contest. During his last five outings he is batting .364 with a double, a home run, two walks and an RBI.
• Jose Ramirez is hitting .231 with 18 doubles, 10 home runs and 53 walks, while slugging .377 with an on-base percentage of .338.
• Among all qualifying players, he is 115th in batting average, 58th in on-base percentage and 117th in slugging percentage.
• Brayan Rocchio has 107 hits this season and has a slash line of .254/.317/.378.
• Rocchio enters this game with three games in a row with at least one hit. During his last five outings he is batting .250 with a double, a home run and an RBI.
• Steven Kwan leads Cleveland with an OBP of .368 this season while batting .266 with 61 walks and 52 runs scored.

Padres Player Leaders

• Fernando Tatis Jr. has racked up an on-base percentage of .353, a slugging percentage of .425, and has 132 hits, all club-highs for the Padres (while batting .280).
• Including all the qualifying hitters in the majors, his batting average puts him 25th, his on-base percentage is 40th, and he is 71st in slugging.
• Manny Machado has 20 doubles, 23 home runs and 55 walks while hitting .215. He's slugging .414 with an on-base percentage of .297.
• He is currently 134th in batting average, 125th in on-base percentage and 86th in slugging percentage among all qualifying hitters.
• Jackson Merrill has 20 doubles, two triples, 19 home runs and 32 walks while hitting .245.
• Xander Bogaerts has 11 doubles, 11 home runs and 56 walks while hitting .223.

Guardians vs Padres Head to Head

• 8/14/2026: 7-5 SD (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: +106)
• 4/2/2025: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 4/1/2025: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 3/31/2025: 7-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/21/2024: 2-1 SD (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/20/2024: 7-0 SD (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/19/2024: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/14/2023: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/13/2023: 6-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/24/2022: 7-0 CLE (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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