Mariners vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 4:11 a.m.

The Seattle Mariners are among the MLB teams busy on Tuesday, versus the Houston Astros.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Mariners vs Astros Game Info

• Seattle Mariners (73-83) vs. Houston Astros (77-79)
• Date: Tuesday, September 22, 2026
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: Mariners.TV and SCHN

Mariners vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-154) | HOU: (+130)
• Spread: SEA: -1.5 (+142) | HOU: +1.5 (-172)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Mariners vs Astros Probable Starting Pitchers

Probable Pitchers: Logan Gilbert (Mariners) - 12-10, 3.69 ERA vs Cristian Javier (Astros) - 2-6, 5.31 ERA

This contest's pitching matchup is set, as the Mariners will send Logan Gilbert (12-10) to the mound, while Cristian Javier (2-6) will take the ball for the Astros. Gilbert's team is 15-15-0 against the spread in his starts this season. Gilbert's team has won 60.9% of his starts when they are favored on the moneyline (14-9). The Astros are 4-7-0 against the spread when Javier starts. The Astros are 1-2 in Javier's three starts this season that they were the moneyline underdog.

Mariners vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (58.2%)

Mariners vs Astros Moneyline

• Looking at the moneyline for Astros-Mariners, Houston is the underdog at +130, and Seattle is -154 playing at home.

Mariners vs Astros Spread

• The Mariners are hosting the Astros and are favored by 1.5 runs (+142 to cover) on the runline. Houston is -172 to cover.

Mariners vs Astros Over/Under

• The Mariners-Astros contest on Sept. 22 has been given an over/under of 7.5 runs. The over is set at -110 and the under at -110.

Bet on Seattle Mariners vs. Houston Astros on FanDuel today!

Mariners vs Astros Betting Trends

• The Mariners have come away with 59 wins in the 119 contests they have been listed as the favorites in this season.
• This season Seattle has been victorious 21 times in 37 chances when named as a favorite of at least -154 on the moneyline.
• The Mariners and their opponents have gone over the total this season in 81 of their 154 opportunities.
• The Mariners are 56-98-0 against the spread in their 154 games with a line set by sportsbooks this season.
• The Astros have compiled a 40-41 record in games they were listed as the moneyline underdog (winning 49.4% of those games).
• When it has played as a moneyline underdog with odds of +130 or longer, Houston has a 6-9 record (winning 40% of its games).
• In the 156 games bookmakers have set an over/under for the Astros, they have combined with opponents to go over the total 76 times (76-73-7).
• The Astros have a 77-79-0 record against the spread this season.

Mariners Player Leaders

• Randy Arozarena has an OPS of .857, fueled by an OBP of .376 to go with a slugging percentage of .481. He has a .279 batting average, as well.
• Among all qualifying batters, he ranks 26th in batting average, his on-base percentage ranks 11th, and he is 25th in slugging.
• Josh Naylor has an OPS of .682, fueled by an OBP of .323 and a team-best slugging percentage of .359 this season. He's batting .268.
• Among qualifying hitters, he ranks 44th in batting average, 83rd in on-base percentage and 123rd in slugging percentage.
• Julio Rodriguez is batting .243 with a .397 slugging percentage and 66 RBI this year.
• Rodriguez enters this matchup with two games in a row with at least one hit. During his last five outings he is batting .316 with three doubles, a walk and an RBI.
• Dominic Canzone has 118 hits, which is best among Seattle hitters this season, while batting .261 with 53 extra-base hits.
• Canzone enters this matchup on a 10-game hitting streak. In his last 10 games he is batting .342 with three doubles, two triples, a home run, five walks and seven RBIs.

Astros Player Leaders

• Yordan Alvarez has accumulated an on-base percentage of .430, a slugging percentage of .597, and has 170 hits, all club-bests for the Astros (while batting .313).
• Including all the qualified hitters in the big leagues, his batting average places him first, his on-base percentage ranks first, and he is first in slugging.
• Alvarez hopes to build on a six-game hitting streak in this matchup. In his last 10 outings he is hitting .294 with three doubles, two home runs, six walks and four RBIs.
• Isaac Paredes is hitting .260 with 26 doubles, a triple, 22 home runs and 67 walks. He's slugging .434 with an on-base percentage of .358.
• He ranks 63rd in batting average, 33rd in on-base percentage and 61st in slugging percentage in the majors.
• Christian Walker is batting .221 with 25 doubles, a triple, 25 home runs and 48 walks.
• Jose Altuve is batting .249 with 24 doubles, two triples, 16 home runs and 40 walks.

Mariners vs Astros Head to Head

• 8/16/2026: 3-2 SEA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/15/2026: 10-5 SEA (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/14/2026: 10-7 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +112)
• 5/14/2026: 8-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/13/2026: 4-3 HOU (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/12/2026: 10-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/11/2026: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/13/2026: 6-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/12/2026: 6-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 4/11/2026: 8-7 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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