Diamondbacks vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 4:11 a.m.

The Arizona Diamondbacks are among the MLB squads in action on Tuesday, versus the Colorado Rockies.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Diamondbacks vs Rockies Game Info

• Arizona Diamondbacks (82-74) vs. Colorado Rockies (57-99)
• Date: Tuesday, September 22, 2026
• Time: 8:40 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: Rockies.TV and Dbacks.TV

Diamondbacks vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-188) | COL: (+158)
• Spread: ARI: -1.5 (-120) | COL: +1.5 (+100)
• Total: 10.5 -- Over: (-132) | Under: (+108)

Diamondbacks vs Rockies Probable Starting Pitchers

Probable Pitchers: Mike Soroka (Diamondbacks) - 8-5, 3.45 ERA vs Kyle Freeland (Rockies) - 4-10, 6.38 ERA

The probable pitchers are Mike Soroka (8-5) for the Diamondbacks and Kyle Freeland (4-10) for the Rockies. Soroka and his team are 9-9-0 ATS this season when he starts. When Soroka starts a game and his team is the favorite on the moneyline, they have a record of 7-5. The Rockies have a 13-12-0 ATS record in Freeland's 25 starts that had a set spread. The Rockies are 9-15 in Freeland's 24 starts this season that they were the moneyline underdog.

Diamondbacks vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (54.8%)

Diamondbacks vs Rockies Moneyline

• Colorado is the underdog, +158 on the moneyline, while Arizona is a -188 favorite despite being on the road.

Diamondbacks vs Rockies Spread

• The Rockies are +1.5 on the run line against the Diamondbacks. The Rockies are +100 to cover, and the Diamondbacks are -120.

Diamondbacks vs Rockies Over/Under

• An over/under of 10.5 has been set for Diamondbacks-Rockies on Sept. 22, with the over being -132 and the under +108.

Bet on Arizona Diamondbacks vs. Colorado Rockies on FanDuel today!

Diamondbacks vs Rockies Betting Trends

• The Diamondbacks have come away with 37 wins in the 66 contests they have been listed as the favorites in this season.
• This season Arizona has come away with a win four times in five chances when named as a favorite of at least -188 on the moneyline.
• The Diamondbacks and their opponents have gone over the total this season in 67 of their 154 opportunities.
• The Diamondbacks are 80-74-0 against the spread in their 154 games that had a posted line this season.
• The Rockies have been the moneyline underdog 149 total times this season. They've finished 54-95 in those games.
• Colorado is 15-41 (winning just 26.8% of its games) when playing as a moneyline underdog of +158 or longer.
• The Rockies have had an over/under set by oddsmakers 153 times, and have combined with opponents to go over the total in 75 of those games (75-75-3).
• The Rockies have an 81-72-0 record ATS this season (covering 52.9% of the time).

Diamondbacks Player Leaders

• Corbin Carroll has 31 doubles, 16 triples, 22 home runs and 72 walks while batting .240. He has an on-base percentage of .331 and a slugging percentage of .470.
• Among qualified batters in baseball, he ranks 98th in batting average, 70th in on-base percentage, and 30th in slugging.
• Ketel Marte is batting .249 with 29 doubles, three triples, 22 home runs and 48 walks. He's slugging .437 with an on-base percentage of .315.
• His batting average is 81st among qualified players, his on-base percentage 96th, and his slugging percentage 58th.
• Gabriel Moreno has 139 hits and an OBP of .386 to go with a slugging percentage of .481.
• Moreno has recorded a hit in two straight games. In his last five games he is hitting .444 with a double, two home runs, four walks and two RBIs.
• Geraldo Perdomo has nine home runs, 52 RBI and a batting average of .256 this season.
• Perdomo enters this matchup on a five-game hitting streak. In his last five games he is hitting .389 with a triple, three walks and two RBIs.

Rockies Player Leaders

• Jake McCarthy has 30 doubles, 13 triples, 15 home runs and 29 walks while batting .297. He's slugging .490 with an on-base percentage of .340.
• Including all the qualifying players in MLB, he is eighth in batting average, 54th in on-base percentage and 19th in slugging percentage.
• McCarthy takes a four-game hitting streak into this matchup. In his last five games he is hitting .300 with three triples, a walk and three RBIs.
• TJ Rumfield's .392 on-base percentage and .451 slugging percentage both pace his team. He has a batting average of .300.
• He is currently seventh in batting average, third in on-base percentage and 47th in slugging percentage among all qualified hitters.
• Hunter Goodman paces the Rockies with 121 hits.
• Kyle Karros has 21 doubles, three triples, 12 home runs and 52 walks while hitting .258.

Diamondbacks vs Rockies Head to Head

• 8/12/2026: 6-4 COL (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +158)
• 8/11/2026: 3-2 COL (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -160, Underdog Moneyline: +148)
• 8/10/2026: 9-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -205, Underdog Moneyline: +186)
• 5/24/2026: 9-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/23/2026: 5-4 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 5/22/2026: 3-2 COL (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/21/2026: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 5/16/2026: 4-2 COL (Favorite: Diamondbacks, Spread: -1.5, Total: 11.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/15/2026: 9-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 11.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/17/2025: 6-5 COL (Favorite: Diamondbacks, Spread: -1.5, Total: 12, Favorite Moneyline: -144, Underdog Moneyline: +122)

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