Dodgers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 4:11 a.m.

The MLB's Tuesday schedule includes the Los Angeles Dodgers facing the San Diego Padres.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Dodgers vs Padres Game Info

• Los Angeles Dodgers (96-60) vs. San Diego Padres (87-69)
• Date: Tuesday, September 22, 2026
• Time: 10:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: TBS, SportsNet LA, and Padres.TV

Dodgers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-120) | SD: (+102)
• Spread: LAD: +1.5 (-184) | SD: -1.5 (+152)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Dodgers vs Padres Probable Starting Pitchers

Probable Pitchers: Yoshinobu Yamamoto (Dodgers) - 14-8, 2.51 ERA vs Michael King (Padres) - 12-9, 3.03 ERA

The probable starters are Yoshinobu Yamamoto (14-8) for the Dodgers and Michael King (12-9) for the Padres. Yamamoto's team is 13-14-0 against the spread this season in his starts. Yamamoto's team has been victorious in 69.2% of the games he's started as the moneyline favorite with a record of 18-8. The Padres have gone 12-19-0 against the spread when King starts. The Padres have a 4-6 record in King's 10 starts this season when they were the moneyline underdog.

Dodgers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (65.8%)

Dodgers vs Padres Moneyline

• Los Angeles is the favorite, -120 on the moneyline, while San Diego is a +102 underdog on the road.

Dodgers vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Dodgers. The Padres are +152 to cover, while the Dodgers are -184 to cover as a 1.5-run underdog on the runline.

Dodgers vs Padres Over/Under

• A total of 8.5 runs has been set for the Dodgers-Padres contest on Sept. 22, with the over available at -102 and the under at -120.

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Dodgers vs Padres Betting Trends

• The Dodgers have come away with 93 wins in the 148 contests they have been listed as the favorites in this season.
• Los Angeles has a record of 88-55 in contests when oddsmakers favor them by -120 or more on the moneyline.
• The Dodgers and their opponents have gone over the total this season in 73 of their 154 opportunities.
• The Dodgers are 65-89-0 against the spread in their 154 games that had a posted line this season.
• The Padres have won 47.9% of the games this season they were the underdog on the moneyline (35-38).
• In games it has played as a moneyline underdog with odds of +102 or longer, San Diego has a 28-31 record (winning 47.5% of its games).
• In the 156 games bookmakers have set an over/under for the Padres, they have combined with opponents to go over the total 74 times (74-79-3).
• The Padres have put together a 90-66-0 record ATS this season (covering 57.7% of the time).

Dodgers Player Leaders

• Freddie Freeman has an OPS of .806, fueled by an OBP of .367 and a team-best slugging percentage of .438 this season. He has a .292 batting average.
• Among all qualified batters in baseball, he ranks ninth in batting average, 16th in on-base percentage, and 57th in slugging.
• Kyle Tucker has 23 doubles, four triples, 17 home runs and 77 walks. He's batting .234 and slugging .393 with an on-base percentage of .334.
• His batting average ranks 106th among qualified players, his on-base percentage 63rd, and his slugging percentage 95th.
• Mookie Betts is batting .259 with a .454 slugging percentage and 67 RBI this year.
• Max Muncy is batting .256 with a .352 OBP and 76 RBI for Los Angeles this season.
• Muncy enters this matchup on a four-game hitting streak. In his last five games he is batting .412 with three doubles, a home run and five RBIs.

Padres Player Leaders

• Fernando Tatis Jr. has 173 hits with a .355 on-base percentage and a .468 slugging percentage, all club-highs for the Padres. He's batting .285.
• Including all the qualified players in the majors, he is 14th in batting average, 39th in on-base percentage and 33rd in slugging percentage.
• Tatis enters this matchup on a four-game hitting streak. In his last five games he is hitting .200 with a double, two home runs, two walks and three RBIs.
• Jackson Merrill has 25 doubles, five triples, 26 home runs and 40 walks while hitting .255. He's slugging .445 with an on-base percentage of .304.
• Including all qualifying players, his batting average puts him 72nd, his on-base percentage ranks 112th, and he is 49th in slugging.
• Manny Machado has 22 doubles, 28 home runs and 75 walks while batting .219.
• Xander Bogaerts is batting .229 with 18 doubles, a triple, 12 home runs and 73 walks.

Dodgers vs Padres Head to Head

• 7/5/2026: 5-2 SD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 7/4/2026: 3-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 7/3/2026: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 7/2/2026: 12-7 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/28/2026: 4-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/27/2026: 15-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/26/2026: 7-1 SD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/20/2026: 4-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 5/19/2026: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/18/2026: 1-0 SD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)

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